To understand the clinical course of human adenoviral (HAdV) conjunctivitis for establishing a better treatment regimen, thirty-eight eyes of 19 patients with HAdV-54 conjunctivitis for less than one week from onset were evaluated for clinical signs and symptoms and DNA copy numbers. It is observed that a viral load of 10⁴–10⁵ is required to develop symptoms of HAdV conjunctivitis, as symptoms were present in all the eyes whose viral load was ≥10⁴ at least once during the course. Next, it is observed that asymptomatic infections in contralateral eyes are common as the virus was detected in most eyes that did not develop conjunctivitis. Furthermore, there was no rapid decrease of the viral load in healed eyes, on the contrary, the viral load in healed eyes on day 15 was significantly higher than in unhealed eyes. This was likely due to corticosteroid instillation that rapidly alleviated symptoms but prolonged the duration of viral shedding. Recently, combination treatment with iodine and corticosteroids has been recommended for HAdV conjunctivitis. Assessing changes in viral load as well as clinical symptoms would be helpful to better understand the clinical course of this disease.

为了了解人类腺病毒 (HAdV) 结膜炎的临床过程以建立更好的治疗方案，对 19 名 HAdV-54 结膜炎患者的 38 只眼进行了评估，这些患者从发病起不到一周，就临床体征和症状以及 DNA 拷贝数进行了评估。据观察，出现 HAdV 结膜炎症状需要10 ⁴ –10 ⁵的病毒载量，因为所有病毒载量≥10 ⁴的眼睛都存在症状 在课程期间至少一次。接下来，观察到对侧眼中的无症状感染很常见，因为在大多数未发生结膜炎的眼睛中检测到病毒。此外，愈合眼的病毒载量没有迅速下降，相反，第15天愈合眼的病毒载量明显高于未愈合眼。这可能是由于皮质类固醇滴注迅速缓解了症状但延长了病毒脱落的持续时间。最近，已推荐碘和皮质类固醇联合治疗 HAdV 结膜炎。评估病毒载量的变化以及临床症状将有助于更好地了解这种疾病的临床过程。