Abstract

In vitro experiments performed on an isolated human endothelial HUVEC cell culture showed that the anxiolytic fabomotizole, which, in addition to the anxiolytic effect, has neuroprotective and cardioprotective activities largely associated with its agonistic action on sigma-1 receptors and shows a pronounced angiogenic activity. Fabomotizole angiogenic activity is realized in the range concentration from 10^–5 to 10^–8 M and is doze-dependent. In the literature, data on the presence of angiogenic activity in sigma receptor agonists have not been previously reported.

中文翻译：

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抗焦虑法博替唑的血管生成作用

摘要

对分离的人内皮 HUVEC 细胞培养物进行的体外实验表明，抗焦虑的 fabomotizole，除了抗焦虑作用外，还具有神经保护和心脏保护活性，主要与其对 sigma-1 受体的激动作用有关，并显示出明显的血管生成活性。Fabomotizole 血管生成活性在 10 ^–5至 10 ^–8 M 的浓度范围内实现，并且依赖于瞌睡。在文献中，以前没有报道过σ受体激动剂中存在血管生成活性的数据。