Knowledge of the Late Paleozoic accretionary processes responsible for the Altaids (or southern Central Asian Orogenic Belt) is critical for a better understanding of continental growth in Central Asia. Here, we systematic study the Late Carboniferous mafic-ultramafic-felsic complexes in eastern Central Tianshan to understand the tectonic evolution of the southern Altaids. Two gabbros yield zircon crystallization ages of 301.5 ± 2.3 Ma and 300.7 ± 2.6 Ma and one granite is dated as 301.6 ± 1.5 Ma. The gabbros are tholeiitic and characterized by typical subduction-related geochemical signatures with low TiO₂ contents, enrichments in Rb, Ba, U, K, Pb and Sr, negative Nb and Ta anomalies, and negative to positive Eu and Ti anomalies. The granites are the A₂-type granites with high contents of SiO₂, K₂O + Na₂O, Ga, Zr, Nb, Y, HFSE, REE, and high ratios of Fe/Mg and Y/Nb (>1.2). The gabbros and granites have high ε_Nd (t) values of +1.64 to +5.03, zircon ε_Hf (t) values of −2.8 to +9.1, and low (⁸⁷Sr/⁸⁶Sr)_i (0.704007–0.705437) values. These geochemical characters demonstrate that the rocks in the complexes are fractionation genesis and that the A-type granitic rocks are the highest fractionation facies of tholeiitic mafic rocks. These results suggest that they were originated from the asthenospheric garnet-free mantle in a supra-subduction zone. Combined with regional data, we suggest that the oblique subduction with slab break-off of the Southern Tianshan oceanic plate plausibly induced asthenospheric upwelling to form the tholeiitic magma, and which intrude along the strike-faults the Central Tianshan-Yamansu arc. Accordingly, these results reveal the Paleo-Asian Ocean continued to subduct at the southern Altaids in the Late Carboniferous.