Variability in psychiatric response following stressful/traumatic life events is frequently observed. There is also variability in propensity for alcohol use disorder (AUD) such that some can consume substantial amounts and not develop AUD symptoms whereas others develop an AUD. Our group has applied discrepancy-based approaches to capture psychiatric resilience (PR) and alcohol resistance (AR), both moderately heritable. This study sought to (1) examine the genetic and environmental correlation of these constructs and (2) model qualitative and quantitative sex effects. Data came from a large twin sample (N = 4501 twin pairs) with self-report measures and interviews assessing distress symptoms, stressful life events, alcohol use, and AUD. Correlated liability model results suggested a moderate degree of genetic correlation between PR and AR (0.54) due to the same genetic factors in males and females. Findings highlight the shared genetic predisposition of these resilience/resistance constructs while emphasizing the impact of unique environmental experiences.

经常观察到压力/创伤性生活事件后精神反应的变化。酒精使用障碍 (AUD) 的倾向也存在差异，因此有些人可以大量饮酒而不会出现 AUD 症状，而其他人则会出现 AUD。我们的小组应用了基于差异的方法来捕捉精神恢复力 (PR) 和酒精抵抗 (AR)，两者都是适度遗传的。本研究旨在 (1) 检查这些结构的遗传和环境相关性，以及 (2) 对定性和定量的性别效应建模。数据来自一个大型双胞胎样本（N = 4501 双胞胎），通过自我报告测量和访谈评估痛苦症状、压力性生活事件、酒精使用和澳元。相关责任模型结果表明 PR 和 AR 之间存在中等程度的遗传相关性（0. 54）由于男性和女性的遗传因素相同。研究结果突出了这些复原力/抵抗力结构的共同遗传倾向，同时强调了独特环境体验的影响。