Ernest Shackleton, an accomplished Antarctic explorer, developed a life-threatening illness during the Discovery Antarctic expedition of 1901–4. His documented signs and symptoms included inflamed gums attributed to scurvy, severe dyspnea, and exercise intolerance, presenting in a setting of nutritional deficiency. Physical examinations at a later date, also following a prolonged diet of limited fresh food, revealed a pulmonary systolic murmur. Thiamine deficiency with cardiomyopathy, either alone or subsequently exacerbated by advanced scurvy, may have been a prominent cause of Shackleton’s condition.

中文翻译：

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欧内斯特·沙克尔顿的体征和症状

欧内斯特·沙克尔顿 (Ernest Shackleton) 是一位成就卓著的南极探险家，在 1901-4 年的“发现南极”探险期间患上了危及生命的疾病。他记录的体征和症状包括因坏血病引起的牙龈发炎、严重呼吸困难和运动不耐受，在营养缺乏的情况下出现。之后的体格检查也是在长期进食有限的新鲜食物后发现肺部收缩期杂音。硫胺素缺乏伴心肌病，无论是单独存在还是随后因晚期坏血病而加剧，可能是沙克尔顿病症的主要原因。