Ferroptosis is a type of regulated cell death that plays an essential role in various brain diseases, including cranial trauma, neuronal diseases, and brain tumors. It has been reported that cancer cells rely on their robust antioxidant capacity to escape ferroptosis. Therefore, ferroptosis exploitation could be an effective strategy to prevent tumor proliferation and invasion. Glioma is a common malignant craniocerebral tumor exhibiting complicated drug resistance and survival mechanisms, resulting in a high mortality rate and short survival time. Recent studies have determined that metabolic alterations in glioma offer exploitable therapeutic targets. These metabolic alterations allow targeted therapy to achieve some initial efficacy but have failed to inhibit glioma growth, invasion, and drug resistance effectively. It has been proposed that the reason for the high malignancy and drug resistance observed with glioma is that these tumors can effectively evade ferroptosis. Ferroptosis-inducing drugs were found to exert a positive effect by targeting this particular characteristic of glioma cells. Moreover, gliomas develop enhanced drug resistance through anti-ferroptosis mechanisms. In this study, we provided an overview of the mechanisms by which glioma aggressiveness and drug resistance are mediated by the evasion of ferroptosis. This information might provide new targets for glioma therapy as well as new insights and ideas for future research.

铁死亡是一种受调控的细胞死亡，在各种脑部疾病中发挥着重要作用，包括颅外伤、神经元疾病和脑肿瘤。据报道，癌细胞依靠其强大的抗氧化能力来逃避铁死亡。因此，利用铁死亡可能是防止肿瘤增殖和侵袭的有效策略。胶质瘤是一种常见的颅脑恶性肿瘤，具有复杂的耐药性和生存机制，死亡率高，生存时间短。最近的研究已经确定，神经胶质瘤的代谢改变提供了可利用的治疗靶点。这些代谢改变使靶向治疗能够达到一些初步疗效，但未能有效抑制神经胶质瘤的生长、侵袭和耐药性。有人提出，在胶质瘤中观察到的高恶性和耐药性的原因是这些肿瘤可以有效地逃避铁死亡。发现诱导铁死亡的药物通过靶向神经胶质瘤细胞的这一特殊特征发挥积极作用。此外，神经胶质瘤通过抗铁死亡机制产生增强的耐药性。在这项研究中，我们概述了神经胶质瘤侵袭性和耐药性由逃避铁死亡介导的机制。这些信息可能为胶质瘤治疗提供新的靶点，并为未来的研究提供新的见解和想法。发现诱导铁死亡的药物通过靶向神经胶质瘤细胞的这一特殊特征发挥积极作用。此外，神经胶质瘤通过抗铁死亡机制产生增强的耐药性。在这项研究中，我们概述了神经胶质瘤侵袭性和耐药性由逃避铁死亡介导的机制。这些信息可能为胶质瘤治疗提供新的靶点，并为未来的研究提供新的见解和想法。发现诱导铁死亡的药物通过靶向神经胶质瘤细胞的这一特殊特征发挥积极作用。此外，神经胶质瘤通过抗铁死亡机制产生增强的耐药性。在这项研究中，我们概述了神经胶质瘤侵袭性和耐药性由逃避铁死亡介导的机制。这些信息可能为胶质瘤治疗提供新的靶点，并为未来的研究提供新的见解和想法。