Neural biomarker of functional disability in major depressive disorder: A structural neuroimaging study,Progress in Neuro-Psychopharmacology and Biological Psychiatry

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Neural biomarker of functional disability in major depressive disorder: A structural neuroimaging study
Progress in Neuro-Psychopharmacology and Biological Psychiatry ( IF 5.6 ) Pub Date : 2021-04-24 , DOI: 10.1016/j.pnpbp.2021.110337
Rubai Zhou ₁ , Jun Chen ₂ , Guoqing Zhao ₃ , Zuowei Wang ₄ , Daihui Peng ₅ , Weiping Xia ₆ , Ruizhi Mao ₅ , Jingjing Xu ₅ , Fan Wang ₅ , Chen Zhang ₅ , Yong Wang ₅ , Chengmei Yuan ₅ , Yousong Su ₅ , Jia Huang ₅ , Tao Yang ₅ , Chenglei Wang ₅ , Lvchun Cui ₅ , Jijun Wang ₇ , Lena Palaniyappan ₈ , Yiru Fang ₂

Affiliation

Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Robarts Research Institute& The Brain and Mind Institute, Western University, London, ON, Canada.
Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200031, China; Shanghai Key Laboratory of Psychotic disorders, Shanghai 201108, China.
Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Department of Psychology, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China.
Hongkou District Mental Health Center of Shanghai, Shanghai 200080, China.
Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China.
Clinical Research Center and Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Department of Medical Psychology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China.
Shanghai Key Laboratory of Psychotic disorders, Shanghai 201108, China; Department of EEG & Neuroimaging, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai 200030, China; Brain Science and Technology Research Center, Shanghai Jiao Tong University, Shanghai, China.
Robarts Research Institute& The Brain and Mind Institute, Western University, London, ON, Canada; Department of Psychiatry, Western University, London, ON, Canada; Lawson Health Research Institute, London, ON, Canada.

Background

Most patients with the major depressive disorder (MDD) have varying degrees of impaired social functioning, and functional improvement often lags behind symptomatic improvement. However, it is still unclear if certain neurobiological factors underlie the deficits of social function in MDD. The aim of this study was to investigate the biomarkers of social function in MDD using structural magnetic resonance imaging (MRI).

Methods

3T anatomical MRI was obtained from 272 subjects including 46 high-functioning (high-SF, Sheehan Disability Scale (SDS) rating < 18) and 63 low-functioning (low-SF, SDS score ≥ 18) patients with MDD and 163 healthy controls (HC). Voxel-based morphometry (VBM) was employed to locate brain regions with grey matter (GM) volume differences in relation to social function in MDD. Regions showing GM differences in relation to social function at baseline were followed up longitudinally in a subset of 38 patients scanned after 12-week treatment.

Results

Volume of right parahippocampal gyrus (rPHG) was significantly reduced in low-SF patients with MDD when compared to high-SF ones (FDR-corrected p < 0.05). Over 12 weeks of follow-up, though SF improved overall, the high and low-SF subgroups continued to differ in their SF, but had no progressive changes in PHG volume.

Limitations

Limited functional assessment, high drop-out rate and median-based grouping method.

Conclusions

Greater GM volume (GMV) of the rPHG may mark better social function in patients with MDD.

中文翻译：

重度抑郁症功能障碍的神经生物标志物：结构性神经影像学研究

背景

大多数患有重度抑郁症（MDD）的患者都有不同程度的社会功能受损，功能改善往往滞后于症状改善。然而，目前尚不清楚某些神经生物学因素是否是 MDD 社会功能缺陷的基础。本研究的目的是使用结构磁共振成像 (MRI) 研究 MDD 中社会功能的生物标志物。

方法

从 272 名受试者中获得 3T 解剖 MRI，包括 46 名高功能（高 SF，Sheehan 残疾量表 (SDS) 评分 < 18）和 63 名低功能（低 SF，SDS 评分 ≥ 18）患有 MDD 的患者和 163 名健康对照(HC)。基于体素的形态计量学 (VBM) 用于定位与 MDD 中的社会功能相关的灰质 (GM) 体积差异的大脑区域。在 12 周治疗后扫描的 38 名患者的子集中，对基线时显示 GM 差异与社会功能相关的区域进行纵向随访。