d-Allulose, a C3 epimer of d-fructose, modulates lipid metabolism. Soy protein has been reported to have anti-dyslipidemic properties. Therefore, we hypothesized that the combination of d-allulose and soy protein would have favorable effects on lipid metabolism. Sprague-Dawley rats were fed 21.7 % casein or 21.7 % soy protein diets with or without 3% d-allulose for 4 weeks under standard (experiment 1) or high-fat conditions (experiment 2). Under the high-fat diet condition, while d-allulose alone increased serum triglyceride levels, co-administration with soy protein suppressed this increase in serum triglyceride levels. Soy protein and d-allulose alone decreased hepatic triglyceride levels under the standard fat diet, and their combination yielded the lowest hepatic triglyceride levels, accompanied by a decrease in hepatic enzyme activities associated with fatty acid synthesis. In conclusion, soy protein and d-allulose co-administration might have additive effects on lipid metabolism, highlighting broader implications for the application of d-allulose in the development of functional foods.

中文翻译：

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d-Allulose和大豆蛋白的共同给药有利地和可加性地改变Sprague-Dawley大鼠的脂质代谢

d -Allulose，的C3差向异构体d -fructose，调节脂质代谢。据报道大豆蛋白具有抗血脂异常的特性。因此，我们假设d-阿洛糖和大豆蛋白的结合对脂质代谢具有有利的影响。在标准（实验1）或高脂条件下（实验2），给Sprague-Dawley大鼠饲喂21.7％的酪蛋白或21.7％的大豆蛋白饲料（含或不含3％d-阿洛糖）4周。在高脂饮食条件下，尽管单独使用d-阿洛糖会增加血清甘油三酯水平，但与大豆蛋白合用会抑制血清甘油三酯水平的这种增加。大豆蛋白和d在标准的脂肪饮食下，单独的β-阿洛糖可降低肝甘油三酯水平，并且它们的组合产生最低的肝甘油三酯水平，并伴随着与脂肪酸合成相关的肝酶活性的降低。总之，大豆蛋白和d-阿洛糖的共同给药可能对脂质代谢产生累加作用，突显了在功能食品开发中对d-阿洛糖的应用具有更广泛的意义。