Atherosclerosis as a common cardiovascular disease is a result of both adverse hemodynamics conditions and monocyte deposition within coronary arteries. It is known that the adhesion of monocytes on the arterial wall and their interaction with the vascular surface are one of the main parameters in the initiation and progression of atherosclerosis. In this work, hemodynamic parameters and monocyte deposition have been investigated in a 3D computational model of the Left Anterior Descending coronary artery (LAD) and its first diagonal branch (D1) under the heart motion. A one-way Lagrangian approach is performed to trace the monocyte particles under different blood flow regimes and heart motion conditions. The hemodynamic results show that the myocardial wall, and also the flow divider wall can be candidates for atheroprone sites. The dynamic movement and pulsatile inlet changed the flow rate between branches about 21% compared to the static case and steady inlet. On the other hand, the calculation of monocytes' depositional behavior illustrates that they settle down downstream the LAD-D1 bifurcation and on the myocardial wall. The deposition rate is closely associated with the inlet type and changing the steady inlet to the sinusoidal and real physiologic profile showed a 150% increase in the deposition rate. These results ensure that the myocardial wall and LAD-D1 bifurcation are the desirable locations for atherosclerosis. These results are in good agreement with the clinical observations.

动脉粥样硬化是一种常见的心血管疾病，是不利的血液动力学状况和冠状动脉内单核细胞沉积的结果。众所周知，单核细胞在动脉壁上的粘附及其与血管表面的相互作用是动脉粥样硬化开始和发展的主要参数之一。在这项工作中，在心脏运动下左前降支冠状动脉（LAD）及其第一对角分支（D1）的3D计算模型中研究了血流动力学参数和单核细胞沉积。执行单向拉格朗日方法来跟踪不同血流状况和心脏运动条件下的单核细胞颗粒。血液动力学结果表明，心肌壁以及分流器壁均可作为动脉粥样硬化部位的候选者。与静态情况和稳定入口相比，动态运动和脉动入口改变了分支之间的流量约21％。另一方面，单核细胞沉积行为的计算表明，它们沉降在LAD-D1分叉的下游和心肌壁上。沉积速率与进样口类型密切相关，将稳定的进样口更改为正弦曲线和真实的生理曲线后，沉积速率增加了150％。这些结果确保心肌壁和LAD-D1分叉是动脉粥样硬化的理想位置。这些结果与临床观察结果非常吻合。沉积行为表明它们沉降在LAD-D1分叉的下游和心肌壁上。沉积速率与进样口类型密切相关，将稳定的进样口更改为正弦曲线和真实的生理曲线后，沉积速率增加了150％。这些结果确保心肌壁和LAD-D1分叉是动脉粥样硬化的理想位置。这些结果与临床观察结果非常吻合。沉积行为表明它们沉降在LAD-D1分叉的下游和心肌壁上。沉积速率与进样口类型密切相关，将稳定的进样口更改为正弦曲线和真实的生理曲线后，沉积速率增加了150％。这些结果确保心肌壁和LAD-D1分叉是动脉粥样硬化的理想位置。这些结果与临床观察结果非常吻合。这些结果确保心肌壁和LAD-D1分叉是动脉粥样硬化的理想位置。这些结果与临床观察结果非常吻合。这些结果确保心肌壁和LAD-D1分叉是动脉粥样硬化的理想位置。这些结果与临床观察结果非常吻合。