Ferroptosis, an iron-dependent form of regulated cell death driven by peroxidative damages of polyunsaturated-fatty-acid-containing phospholipids in cellular membranes, has recently been revealed to play an important role in radiotherapy-induced cell death and tumor suppression, and to mediate the synergy between radiotherapy and immunotherapy. In this review, we summarize known as well as putative mechanisms underlying the crosstalk between radiotherapy and ferroptosis, discuss the interactions between ferroptosis and other forms of regulated cell death induced by radiotherapy, and explore combination therapeutic strategies targeting ferroptosis in radiotherapy and immunotherapy. This review will provide important frameworks for future investigations of ferroptosis in cancer therapy.

铁死亡是一种由细胞膜中含多不饱和脂肪酸的磷脂的过氧化损伤驱动的铁依赖性调节细胞死亡形式，最近发现在放射治疗诱导的细胞死亡和肿瘤抑制中发挥重要作用，并介导放射治疗与免疫治疗的协同作用。在这篇综述中，我们总结了放射治疗与铁死亡之间串扰的已知和推定机制，讨论了铁死亡与放疗诱导的其他形式的调节性细胞死亡之间的相互作用，并探索了放射治疗和免疫治疗中针对铁死亡的联合治疗策略。这篇综述将为未来癌症治疗中铁死亡的研究提供重要的框架。