The flavivirus genus consists of several major human pathogens including dengue (DENV) and Zika viruses. The flavivirus nonstructural protein 1 (NS1) plays an important role in disease progression, for example, in the development of severe dengue disease. Anti-NS1 antibodies have been shown to confer protection, and two new studies by Biering et al. and Modhiran et al. on the structure of NS1:antibody complexes reveal their mechanism of neutralization.

中文翻译：

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NS1 抗体如何预防严重的黄病毒病

黄病毒属由几种主要的人类病原体组成，包括登革热 (DENV) 和寨卡病毒。黄病毒非结构蛋白 1 (NS1) 在疾病进展中起着重要作用，例如，在严重登革热病的发展中。抗 NS1 抗体已被证明可以提供保护，Biering等人的两项新研究。和莫迪兰等人。NS1：抗体复合物的结构揭示了它们的中和机制。