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Differential Effects of Various Androgens on Polycystic Ovary Syndrome
Hormone and Metabolic Research ( IF 2.2 ) Pub Date : 2021-04-20 , DOI: 10.1055/a-1422-3243
Sebastião Freitas de Medeiros 1, 2 , Bruna Barcelo Barbosa 2 , Ana Karine Lin Winck Yamamoto de Medeiros 2, 3 , Matheus Antônio Souto de Medeiros 2 , Márcia Marly Winck Yamamoto 2
Affiliation  

The hyperandrogenism in polycystic ovary syndrome (PCOS) is associated with the risk for the future development of the cardiovascular disease. The objective of the study is to verify whether different androgens have the same harmful effect. This cross-sectional study enrolled 823 women with PCOS: 627 (76.2%) with biochemical hyperandrogenism and 196 (23.8%) with normal androgen levels. The role of individual androgen was evaluated using univariate and multivariate logistic regression. In normoandrogenemic PCOS (NA-PCOS), free androgen index (FAI) predicted significant abnormality in visceral adipose index (VAI, OR=9.2, p=0.002) and dehydroepiandrosterone (DHEA) predicted against alteration in β-cell function (OR=0.5, p=0.007). In hyperandrogenemic PCOS (HA-PCOS), FAI predicted derangements in waist triglyceride index (WTI), VAI, and lipid accumulation product (LAP) (OR ranging from 1.6 to 5.8, p<0.05). DHEA weakly predicted against VAI (OR 0.7, p=0.018), dehydroepiandrosterone sulfate (DHEAS) tended to predict against the conicity index (OR=0.7, p=0.037). After multiple regression, FAI retained significant strength to predict various anthropometric and metabolic abnormalities (OR ranging from 1.1 to 3.0, p<0.01), DHEA was kept as a protector factor against WTI, LAP, and VAI (OR ranging from 0.6 to 0.9; p<0.01) and DHEAS against the conicity index (OR=0.5, p<0.001). In conclusion, the free androgen index was the most powerful predictor of anthropometric and metabolic abnormalities of polycystic ovary syndrome. Conversely, DHEA and DHEAS demonstrated protective effects against disorders in some markers of obesity and abnormal metabolism.

中文翻译:

各种雄激素对多囊卵巢综合征的不同作用

多囊卵巢综合征 (PCOS) 中的高雄激素血症与心血管疾病未来发展的风险相关。该研究的目的是验证不同的雄激素是否具有相同的有害作用。这项横断面研究招募了 823 名患有 PCOS 的女性:627 名 (76.2%) 具有生化雄激素过多症,196 名 (23.8%) 具有正常雄激素水平。使用单变量和多变量逻辑回归评估个体雄激素的作用。在雄激素正常的 PCOS (NA-PCOS) 中,游离雄激素指数 (FAI) 预测内脏脂肪指数 (VAI, OR=9.2, p=0.002) 和脱氢表雄酮 (DHEA) 的显着异常,预测 β 细胞功能的改变 (OR=0.5) ,p=0.007)。在高雄激素 PCOS (HA-PCOS) 中,FAI 预测腰甘油三酯指数 (WTI)、VAI、和脂质积累产物 (LAP)(OR 范围为 1.6 至 5.8,p<0.05)。DHEA 对 VAI 预测较弱(OR 0.7,p=0.018),硫酸脱氢表雄酮(DHEAS)倾向于预测锥度指数(OR=0.7,p=0.037)。多元回归后,FAI 在预测各种人体测量和代谢异常(OR 范围为 1.1 至 3.0,p < 0.01)方面保持显着优势,DHEA 仍作为 WTI、LAP 和 VAI 的保护因子(OR 范围为 0.6 至 0.9; p<0.01) 和 DHEAS 对锥度指数 (OR=0.5, p<0.001)。总之,游离雄激素指数是多囊卵巢综合征人体测量和代谢异常最有力的预测指标。相反,DHEA 和 DHEAS 在肥胖和代谢异常的某些标志物中显示出对疾病的保护作用。
更新日期:2021-04-22
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