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Plasma Cytokine Levels As Predictors of Global and Domain-Specific Human Immunodeficiency Virus-Associated Neurocognitive Impairment in Treatment-Naive Individuals
Journal of Interferon & Cytokine Research ( IF 2.3 ) Pub Date : 2021-04-19 , DOI: 10.1089/jir.2020.0251
Vurayai Ruhanya 1, 2 , Graeme B Jacobs 1 , Robert Paul 3 , John Joska 4 , Soraya Seedat 5 , George Nyandoro 2 , Susan Engelbrecht 1, 6 , Richard H Glashoff 6, 7
Affiliation  

Central nervous system dysfunction, associated with human immunodeficiency virus (HIV) infection, remains a significant clinical concern, affecting at least 50% of infected people. Imbalances in cytokine expression levels have been linked to HIV-associated neurocognitive disorders. The aim of this study was to evaluate plasma cytokine levels as predictor neurocognitive impairment in HIV infection using a multiplex profiling kit. Stepwise regression model was used to identify cytokine biomarkers of overall and domain-specific cognitive performance. Higher interleukin (IL)-2 (β = 0.04; P = 0.001) and eotaxin (β = 0.01; P = 0.017) were predictors of global neurocognitive, whereas higher IL-5 (β = 0.005; P = 0.007) was negative predictor of global cognitive deficit. IL-2 was a negative predictor of most cognitive domain functions, including recall (β = 0.24; P = 0.005), recognition (β = 0.04; P = 0.026), mental control (β = 0.38; P = 0.005), symbol search (β = −0.55; P = 0.001), and digital symbol (β = −0.79; P = 0.019). IL-6 was associated with 3 impaired domains, mental processing (β = −0.468; P = 0.027), recognition (β = −0.044; P = 0.012), and learning (β = 0.02668; P = 0.020) These results show that plasma cytokines/chemokines may serve as markers of neurocognitive impairment in HIV infection.

中文翻译:

血浆细胞因子水平作为全球和特定领域人类免疫缺陷病毒相关神经认知障碍的预测因子

与人类免疫缺陷病毒 (HIV) 感染相关的中枢神经系统功能障碍仍然是一个重要的临床问题,影响至少 50% 的感染者。细胞因子表达水平的失衡与 HIV 相关的神经认知障碍有关。本研究的目的是使用多重分析试剂盒评估血浆细胞因子水平作为 HIV 感染中神经认知障碍的预测指标。逐步回归模型用于识别整体和特定领域认知表现的细胞因子生物标志物。较高的白细胞介素 (IL)-2 ( β  = 0.04; P  = 0.001) 和嗜酸性粒细胞趋化因子 ( β  = 0.01; P  = 0.017) 是整体神经认知的预测因子,而较高的 IL-5 ( β  = 0.005;P  = 0.007)是全球认知缺陷的负预测因子。IL-2 是大多数认知域功能的负预测因子,包括回忆(β  = 0.24;P  = 0.005)、识别(β  = 0.04;P  = 0.026)、心理控制(β  = 0.38;P  = 0.005)、符号搜索( β  = -0.55; P  = 0.001) 和数字符号 ( β  = -0.79; P  = 0.019)。IL-6 与 3 个受损领域相关,即心理处理(β  = -0.468;P  = 0.027)、识别(β  = -0.044;P  = 0.012)和学习(β  = 0.02668;P  = 0.020) 这些结果表明血浆细胞因子/趋化因子可作为 HIV 感染中神经认知障碍的标志物。
更新日期:2021-04-22
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