Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional responses in metabolic tissues. Here we review advances in our understanding of the gene regulatory networks that contribute to hepatic responses to fasting and feeding. The advent of sequencing and -omics techniques have begun to facilitate a holistic understanding of the transcriptional landscape and its plasticity. We highlight transcription factors, their cofactors, and the pathways that they impact. We also discuss physiological factors that impinge on these responses, including circadian rhythms and sex differences. Finally, we review how dietary modifications modulate hepatic gene expression programs.

中文翻译：

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对禁食和进食的肝脏转录反应

哺乳动物经历规律的禁食和进食循环，在代谢组织中参与动态转录反应。在这里，我们回顾了我们对有助于肝脏对禁食和进食反应的基因调控网络的理解方面的进展。测序和组学技术的出现已经开始促进对转录景观及其可塑性的整体理解。我们重点介绍了转录因子、它们的辅因子以及它们影响的途径。我们还讨论了影响这些反应的生理因素，包括昼夜节律和性别差异。最后，我们回顾了饮食改变如何调节肝脏基因表达程序。