Our laboratory has demonstrated that functional N-methyl-d-aspartate-like receptors are present on neuronal mitochondria (NMDA_m). This novel site gates the influx of Ca²⁺ and causes a several-fold increase in ATP levels. Although elevations in ATP in other cell types have been linked to increases in mitochondrial Ca²⁺, it has not been established whether the same holds true for calcium uptake via NMDA_m. In this study, we have investigated the effect of NMDA_m activation on a variety of bioenergetic parameters. Our findings suggest that mitochondrial bioenergetics are not only modulated by NMDA_m activation in a Ca²⁺-dependent but also in a Ca²⁺-independent manner.

我们的实验室已经证明功能性 N-甲基-d-天冬氨酸样受体存在于神经元线粒体 (NMDA _m ) 上。这个新的位点限制了 Ca ²⁺的流入并导致 ATP 水平增加数倍。虽然其他细胞类型中 ATP 的升高与线粒体 Ca ²⁺的增加有关，但尚未确定是否同样适用于通过 NMDA _m吸收钙。在这项研究中，我们研究了 NMDA _m活化对各种生物能量参数的影响。我们的研究结果表明，线粒体生物能量学不仅受Ca ^{2+中 NMDA} _m激活的调节。依赖但也以不依赖Ca ²⁺的方式。