Background: Hereditary angioedema (HAE) is associated with relevant disease-related burden. We aimed at investigating prevalence of depression and anxiety in patients with HAE in Leipzig, Germany. Methods: Questionnaire-based evaluation of medical history, Angioedema Control Test (AECT), Angioedema Quality of Life Questionnaire (AE-QoL), Generalized Anxiety Disorder Scale-7 (GAD-7), and Hospital Anxiety and Depression Scale (HADS). Results: Thirty-seven patients with HAE were included (31 females, mean age 49.6 ± 17.5 years). A mean diagnostic delay between first symptoms and correct diagnosis of 14.2 ± 14.5 years was detected. Patients aged #x3c;50 years (n = 18) had been diagnosed significantly earlier with HAE than older patients (p = #x3c;0.001). In 6 patients (16.2%), unnecessary medical interventions were performed and 14 patients (43.8%) reported at least 1 HAE-related death of a family member. Psychological stress was the most common triggering factor (96.2%). HADS scores revealed depression in 5/37 patients (13.5%) and anxiety in 16/37 (43.2%), GAD-7 score indicated anxiety in 9/36 (25%) participants. Patients receiving long-term prophylactic treatment (n = 17, 45.9%) showed significantly better disease control (AECT; p = #x3c;0.001) and quality of life (AE-QoL; p = #x3c;0.001) compared to those with on-demand treatment only. Patients with long-term prophylactic treatment showed significantly lower scores for anxiety and depression at GAD-7 (p = 0.011) and HADS (anxiety: p = 0.021; depression: p = 0.008). In 5 patients, treatment regime was changed as AECT score indicated insufficient disease control. Subsequently, we measured significant improvement of quality of life (AE-QoL, p = 0.04) and disease control (AECT; p = 0.032). Conclusion: Anxiety was a frequent burden in our study group and showed a significant association with low disease control. Our data indicate that prophylactic HAE treatment can improve psychosocial burden of HAE.
Int Arch Allergy Immunol

中文翻译：

---

遗传性血管性水肿的预防性治疗与德国莱比锡患者的焦虑减少有关

背景：遗传性血管性水肿 (HAE) 与相关疾病相关负担相关。我们旨在调查德国莱比锡 HAE 患者的抑郁和焦虑患病率。方法：基于问卷的病史评估、血管性水肿控制测试 (AECT)、血管性水肿生活质量问卷 (AE-QoL)、广泛性焦虑症量表 7 (GAD-7) 和医院焦虑和抑郁量表 (HADS)。结果：包括 37 名 HAE 患者（31 名女性，平均年龄 49.6 ± 17.5 岁）。检测到第一个症状和正确诊断之间的平均诊断延迟为 14.2 ± 14.5 年。#x3c;50 岁的患者 ( n = 18) 被诊断为 HAE 的时间明显早于老年患者 (p = #x3c;0.001)。6 名患者 (16.2%) 进行了不必要的医疗干预，14 名患者 (43.8%) 报告至少有 1 名家庭成员因 HAE 相关死亡。心理压力是最常见的触发因素（96.2%）。HADS 评分显示 5/37 (13.5%) 患者抑郁，16/37 (43.2%) 患者焦虑，GAD-7 评分显示 9/36 (25%) 参与者焦虑。接受长期预防性治疗的患者 ( n = 17, 45.9%) 与接受长期预防性治疗的患者相比，疾病控制 (AECT; p = #x3c;0.001) 和生活质量 (AE-QoL; p = #x3c;0.001 ) 明显更好仅限按需治疗。接受长期预防性治疗的患者在 GAD-7 中的焦虑和抑郁得分显着降低 ( p= 0.011）和 HADS（焦虑：p = 0.021；抑郁：p = 0.008）。在 5 名患者中，由于 AECT 评分表明疾病控制不足，因此改变了治疗方案。随后，我们测量了生活质量（AE-QoL，p = 0.04）和疾病控制（AECT；p = 0.032）的显着改善。结论：焦虑是我们研究组的常见负担，并且与疾病控制不佳显着相关。我们的数据表明，预防性 HAE 治疗可以改善 HAE 的社会心理负担。
Int Arch 过敏免疫学