The increasing cure rate of cancer has led to a vast population of survivors having to face the late adverse effects of oncological treatments, with fertility impairment being one of the most sensitive issues for patients. Different options to preserve the fertility of adult patients are routinely used in clinical practice. However, fertility preservation strategies for prepubertal patients at risk of infertility are limited to the cryopreservation of immature gonadal tissue. In recent decades, many research efforts have been focused on the future use of cryopreserved gonadal tissue. This review discusses the common status of fertility preservation measures for pediatric patients undergoing gonadotoxic treatment, focusing especially on the challenges that remain to be solved in order to implement this fundamental service.
Horm Res Paediatr

中文翻译：

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有不孕风险的青春期前患者的生育保护：现状和未来展望

癌症治愈率的提高导致大量幸存者不得不面对肿瘤治疗的晚期不良反应，生育障碍是患者最敏感的问题之一。临床实践中经常使用不同的选择来保护成年患者的生育能力。然而，有不孕风险的青春期前患者的生育力保存策略仅限于未成熟性腺组织的冷冻保存。近几十年来，许多研究工作都集中在冷冻保存的性腺组织的未来用途上。本综述讨论了接受性腺毒性治疗的儿科患者生育力保留措施的普遍状况，特别关注为实施这一基本服务而仍有待解决的挑战。
儿科研究