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miR-124: A Promising Therapeutic Target for Central Nervous System Injuries and Diseases
Cellular and Molecular Neurobiology ( IF 4 ) Pub Date : 2021-04-22 , DOI: 10.1007/s10571-021-01091-6
Jinying Xu 1 , Yangyang Zheng 1 , Liangjia Wang 2 , Yining Liu 2 , Xishu Wang 2 , Yulin Li 1 , Guangfan Chi 1
Affiliation  

Central nervous system injuries and diseases, such as ischemic stroke, spinal cord injury, neurodegenerative diseases, glioblastoma, multiple sclerosis, and the resulting neuroinflammation often lead to death or long-term disability. MicroRNAs are small, non-coding, single-stranded RNAs that regulate posttranscriptional gene expression in both physiological and pathological cellular processes, including central nervous system injuries and disorders. Studies on miR-124, one of the most abundant microRNAs in the central nervous system, have shown that its dysregulation is related to the occurrence and development of pathology within the central nervous system. Herein, we review the molecular regulatory functions, underlying mechanisms, and effective delivery methods of miR-124 in the central nervous system, where it is involved in pathological conditions. The review also provides novel insights into the therapeutic target potential of miR-124 in the treatment of human central nervous system injuries or diseases.



中文翻译:

miR-124:中枢神经系统损伤和疾病的有希望的治疗靶点

中枢神经系统损伤和疾病,例如缺血性中风、脊髓损伤、神经退行性疾病、胶质母细胞瘤、多发性硬化症,以及由此产生的神经炎症常常导致死亡或长期残疾。MicroRNA 是小的非编码单链 RNA,可在生理和病理细胞过程(包括中枢神经系统损伤和疾病)中调节转录后基因的表达。对中枢神经系统中最丰富的微小RNA之一miR-124的研究表明,其失调与中枢神经系统内病理的发生和发展有关。在此,我们回顾了 miR-124 在中枢神经系统中的分子调控功能、潜在机制和有效递送方法,它涉及病理状况。该综述还为 miR-124 在治疗人类中枢神经系统损伤或疾病中的治疗靶点潜力提供了新的见解。

更新日期:2021-04-22
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