There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA-ergic inhibitory interneurons. The present study tested whether the long-acting oxytocin-analogue carbetocin has anti-nociceptive effects in multi-modal experimental pain in humans.

中文翻译：

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催产素受体调节对健康志愿者的抗伤害作用——一项随机、双盲、安慰剂对照研究

越来越多的证据表明催产素是脊髓伤害性过程中的神经递质。下丘脑催产素能神经元投射到脊髓背角，在那里它们激活 GABA 能抑制性中间神经元。本研究测试了长效催产素类似物卡贝缩宫素在人类多模式实验性疼痛中是否具有抗伤害性作用。