Hostility is a complex personality trait associated with many cardiovascular risk factor phenotypes. Although magnesium intake has been related to mood and cardio-metabolic disease, its relation with hostility remains unclear. We hypothesize that high total magnesium intake is associated with lower levels of hostility because of its putative antidepressant mechanisms. To test the hypothesis, we prospectively analyzed data in 4,716 young adults aged 18-30 years at baseline (1985-1986) from four U.S. cities over five years of follow-up using data from the Coronary Artery Risk Development in Young Adults (CARDIA) study. Magnesium intake was estimated from a dietary history questionnaire plus supplements at baseline. Levels of hostility were assessed using the Cook-Medley scale at baseline and year 5 (1990-1991). Generalized estimating equations were applied to estimate the association of magnesium intake with hostility as repeated measures at the two time-points (baseline and year 5). General linear model was used to determine the association between magnesium intake and change in hostility over 5 years. After adjustment for socio-demographic and major lifestyle factors, a significant inverse association was observed between magnesium intake and hostility level over 5 years of follow-up. Beta coefficients (95% CI) across higher quintiles of magnesium intake were 0 (reference), -1.28 (-1.92, -0.65), -1.45 (-2.09, -0.81), -1.41 (-2.08, -0.75) and -2.16 (-2.85, -1.47), respectively (P_linear-trend<.01). The inverse association was independent of socio-demographic and major lifestyle factors, supplement use, and depression status at year 5. This prospective study provides evidence that in young adults, high magnesium intake was inversely associated with hostility level independent of socio-demographic and major lifestyle factors.

敌意是一种复杂的人格特质，与许多心血管危险因素表型相关。尽管镁摄入量与情绪和心脏代谢疾病有关，但其与敌意的关系仍不清楚。我们假设，由于镁的假定抗抑郁机制，高总镁摄入量与较低水平的敌意有关。为了检验这一假设，我们利用来自年轻人冠状动脉风险发展 (CARDIA) 的数据，对来自美国四个城市的 4,716 名 18-30 岁年轻人的基线数据（1985-1986 年）进行了五年随访的前瞻性分析。学习。镁的摄入量是根据饮食史调查问卷加上基线补充剂来估计的。在基线和第 5 年（1990-1991 年）使用 Cook-Medley 量表评估敌意程度。应用广义估计方程来估计镁摄入量与敌意之间的关联，并在两个时间点（基线和第 5 年）重复测量。使用一般线性模型来确定 5 年内镁摄入量与敌意变化之间的关联。在调整社会人口统计和主要生活方式因素后，在 5 年的随访中观察到镁摄入量和敌意水平之间存在显着的负相关。镁摄入量较高五分位数的 Beta 系数 (95% CI) 分别为 0（参考）、-1.28 (-1.92, -0.65)、-1.45 (-2.09, -0.81)、-1.41 (-2.08, -0.75) 和 -分别为 2.16 (-2.85, -1.47) ( P_线性趋势<.01)。这种负相关与社会人口统计和主要生活方式因素、补充剂使用情况以及第 5 年的抑郁状况无关。这项前瞻性研究提供的证据表明，在年轻人中，高镁摄入量与敌意水平呈负相关，与社会人口统计和主要生活方式因素无关。生活方式因素。