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BC-TFdb: a database of transcription factor drivers in breast cancer
Database: The Journal of Biological Databases and Curation ( IF 5.8 ) Pub Date : 2021-04-10 , DOI: 10.1093/database/baab018
Abbas Khan 1 , Taimoor Khan 1 , Syed Nouman Nasir 2 , Syed Shujait Ali 2 , Muhammad Suleman 2 , Muhammad Rizwan 2 , Muhammad Waseem 3 , Shahid Ali 2 , Xia Zhao 4 , Dong-Qing Wei 1, 5, 6
Affiliation  

Transcription factors (TFs) are DNA-binding proteins, which regulate many essential biological functions. In several cancer types, TF function is altered by various direct mechanisms, including gene amplification or deletion, point mutations, chromosomal translocations, expression alterations, as well as indirectly by non-coding DNA mutations influencing the binding of the TF. TFs are also actively involved in breast cancer (BC) initiation and progression. Herein, we have developed an open-access database, BC-TFdb (Breast Cancer Transcription Factors database), of curated, non-redundant TF involved in BC. The database provides BC driver TFs related information including genomic sequences, proteomic sequences, structural data, pathway information, mutations information, DNA binding residues, survival and therapeutic resources. The database will be a useful platform for researchers to obtain BC-related TF–specific information. High-quality datasets are downloadable for users to evaluate and develop computational methods for drug designing against BC. Database URL: https://www.dqweilab-sjtu.com/index.php.

中文翻译:

BC-TFdb:乳腺癌转录因子驱动数据库

转录因子 (TF) 是 DNA 结合蛋白,可调节许多重要的生物学功能。在几种癌症类型中,TF 功能通过各种直接机制改变,包括基因扩增或缺失、点突变、染色体易位、表达改变,以及通过影响 TF 结合的非编码 DNA 突变间接改变。TFs 还积极参与乳腺癌 (BC) 的发生和进展。在此,我们开发了一个开放存取数据库 BC-TFdb(乳腺癌转录因子数据库),其中包含与 BC 相关的精选非冗余 TF。该数据库提供BC驱动TFs相关信息,包括基因组序列、蛋白质组序列、结构数据、通路信息、突变信息、DNA结合残基、存活和治疗资源。该数据库将成为研究人员获取 BC 相关 TF 特定信息的有用平台。用户可以下载高质量的数据集,以评估和开发针对 BC 进行药物设计的计算方法。数据库网址:https://www.dqweilab-sjtu.com/index.php。
更新日期:2021-04-10
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