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Determination of the route of excretion of robenacoxib (Onsior™) in cats and dogs: A pilot study
Journal of Veterinary Pharmacology and Therapeutics ( IF 1.3 ) Pub Date : 2021-04-21 , DOI: 10.1111/jvp.12973
Jonathan N King 1 , Martin Jung 1
Affiliation  

The objective of the studies was to determine the route of excretion, faecal or urinary, of the nonsteroidal anti-inflammatory drug (NSAID) robenacoxib (Onsior™) in cats and dogs. The studies employed a two-part crossover design in 4 beagle dogs (2 female and 2 male, age 36–41 months and body weight 9.0–10.3 kg) and a parallel group comparison of two groups each of 3 domestic short-hair cats (2 female and 4 castrated male, age 35–73 months and body weight 3.0–5.7 kg). Animals were administered single doses of 1 (dog) or 2 (cat) mg/kg of [14C]-robenacoxib by intravenous (IV) and oral routes. Venous blood samples were taken and analysed for robenacoxib concentration. Faeces and urine were collected for 4 (cats) or 7 (dogs) days and analysed for radioactivity. Robenacoxib was eliminated rapidly from blood (≤ 8 hr). In dogs, expressed as the percentage of the administered dose and adjusted so that faecal plus urine recovery was 100%, the mean (SD) excretion in faeces and urine was, respectively, 64.6% (4.30) and 35.4% (4.3) after IV and 66.7% (6.9) and 33.3% (6.9) after oral administration. The respective values in cats, in faeces and urine, were 72.5% (4.6) and 27.5% (4.6) after IV and 78.5% (2.6) and 21.5% (2.6) after oral administration. In conclusion, excretion of systemically available robenacoxib in cats and dogs was mixed via both faeces and urine, but predominately faecal (~64.6% in dogs and ~72.5% in cats) and assumed to be via biliary excretion.

中文翻译:

确定罗贝昔布 (Onsior™) 在猫和狗中的排泄途径:一项初步研究

研究的目的是确定猫和狗中非甾体抗炎药 (NSAID) robenacoxib (Onsior™) 的排泄途径、粪便或尿液。该研究对 4 只比格犬(2 只雌性和 2 只雄性,年龄 36-41 个月,体重 9.0-10.3 公斤)采用两部分交叉设计,并对 3 只家养短毛猫各两组进行平行组比较( 2 名女性和 4 名去势男性,年龄 35-73 个月,体重 3.0-5.7 公斤)。动物被给予单剂量的 1(狗)或 2(猫)mg/kg [ 14C]-robenacoxib 通过静脉内 (IV) 和口服途径。采集静脉血样并分析罗贝考昔浓度。收集粪便和尿液 4 天(猫)或 7 天(狗)并分析放射性。罗贝那昔布迅速从血液中消除(≤ 8 小时)。在狗中,以给药剂量的百分比表示并进行调整以使粪便和尿液的回收率为 100%,IV 后粪便和尿液中的平均 (SD) 排泄量分别为 64.6% (4.30) 和 35.4% (4.3)口服给药后分别为 66.7% (6.9) 和 33.3% (6.9)。在猫的粪便和尿液中,IV 后分别为 72.5% (4.6) 和 27.5% (4.6),口服后分别为 78.5% (2.6) 和 21.5% (2.6)。总之,猫和狗体内全身可用的罗贝考昔的排泄是通过粪便和尿液混合的,但主要是粪便(~64.
更新日期:2021-06-03
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