N-methyl-2-pyrrolidone (NMP) and γ-hydroxybutyrate acid (GHB) are synthetic solvents detected in the recreational drug market. GHB has sedative/hypnotic properties and is used for criminal purposes to compromise reaction ability and commit drug-facilitated sexual assaults and other crimes. NMP is a strong solubilizing solvent that has been used alone or mixed with GHB in case of abuse and robberies. The aim of this experimental study is to compare the acute pharmaco-toxicological effects of NMP and GHB on neurological signs (myoclonia, convulsions), sensorimotor (visual, acoustic, and overall tactile) responses, righting reflex, thermoregulation, and motor activity (bar, drag, and accelerod test) in CD-1 male mice. Moreover, since cardiorespiratory depression is one of the main adverse effects related to GHB intake, we investigated the effect of NMP and GHB on cardiorespiratory changes (heart rate, breath rate, oxygen saturation, and pulse distension) in mice. The present study demonstrates that NMP inhibited sensorimotor and motor responses and induced cardiorespiratory depression, with a lower potency and efficacy compared to GHB. These results suggest that NMP can hardly be used alone as a substance to perpetrate sexual assault or robberies.

N-甲基-2-吡咯烷酮（NMP）和γ-羟基丁酸（GHB）是休闲药市场上发现的合成溶剂。GHB具有镇静/催眠作用，可用于犯罪目的，以削弱反应能力并实施毒品促性侵犯和其他犯罪。NMP是一种强溶解性溶剂，一旦滥用和抢劫，可单独使用或与GHB混合使用。这项实验研究的目的是比较NMP和GHB对神经系统症状（肌阵挛，抽搐），感觉运动（视觉，听觉和整体触觉）响应，扶正反射，体温调节和运动活动（酒吧）的急性药理毒理作用。 ，阻力和加速试验）在CD-1雄性小鼠中进行。此外，由于心肺抑郁是与GHB摄入量相关的主要不良反应之一，我们研究了NMP和GHB对小鼠心肺变化（心率，呼吸率，血氧饱和度和脉搏扩张）的影响。本研究表明，与GHB相比，NMP抑制感觉运动和运动反应并诱发心肺抑郁，其效力和功效较低。这些结果表明，NMP几乎不能单独用作进行性侵犯或抢劫的物质。