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Can discourse processing performance serve as an early marker of Alzheimer’s disease and mild cognitive impairment? A systematic review of text comprehension
European Journal of Ageing ( IF 3.721 ) Pub Date : 2021-04-20 , DOI: 10.1007/s10433-021-00619-5
Eesha Kokje 1 , Simge Celik 1 , Hans-Werner Wahl 1 , Christiane von Stutterheim 2
Affiliation  

A number of linguistic and cognitive deficits have been reported during the course of Alzheimer’s disease (AD) and its preceding stage of mild cognitive impairment (MCI), with some deficits appearing years before onset of clinical symptoms. It continues to be a critical task to identify tools that may serve as an early marker of pathology that are also reliably able to distinguish AD from normal ageing. Given the limited success of classic psychometric cognitive testing, a novel approach in assessment is warranted. A potentially sensitive assessment paradigm is discourse processing. The aim of this review was to synthesize original research studies investigating comprehension of discourse in AD and MCI, and to evaluate the potential of this paradigm as a promising avenue for further research. A literature search targeting studies with AD or MCI groups over 60 years of age was conducted in PubMed, Web of Science, and PsycINFO databases. Eight articles with good quality were included in the review. Six measures of discourse comprehension—naming latency, summary, lesson, main idea, proportion of inferential clauses, true/false questions—were identified. All eight studies reported significant deficits in discourse comprehension in AD and MCI groups on five of the six measures, when compared to cognitively healthy older adults. Mixed results were observed for associations with commonly used cognitive measures. Given the consistent findings for discourse comprehension measures across all studies, we strongly recommend further research on its early predictive potential, and discuss different avenues for research.



中文翻译:

话语加工能力可以作为阿尔茨海默病和轻度认知障碍的早期标志物吗?对文本理解的系统评价

在阿尔茨海默病 (AD) 和轻度认知障碍 (MCI) 的早期阶段,已经报告了许多语言和认知缺陷,其中一些缺陷出现在临床症状出现前数年。识别可以作为病理早期标志物的工具仍然是一项关键任务,这些工具也能够可靠地将 AD 与正常衰老区分开来。鉴于经典心理测量认知测试的成功有限,有必要采用一种新的评估方法。一个潜在敏感的评估范式是话语处理。本综述的目的是综合调查 AD 和 MCI 中话语理解的原始研究,并评估这种范式作为进一步研究的有希望的途径的潜力。在 PubMed、Web of Science 和 PsycINFO 数据库中进行了针对 60 岁以上 AD 或 MCI 组研究的文献检索。8篇质量好的文章被纳入审查。确定了六个话语理解的度量——命名延迟、摘要、课程、主要思想、推理从句的比例、真/假问题。与认知健康的老年人相比,所有八项研究都报告了在六项措施中的五项中 AD 和 MCI 组的话语理解存在显着缺陷。对于与常用认知测量的关联,观察到混合结果。鉴于所有研究中话语理解措施的一致发现,我们强烈建议进一步研究其早期预测潜力,并讨论不同的研究途径。

更新日期:2021-04-20
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