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Mouse middle-ear forward and reverse acoustics
The Journal of the Acoustical Society of America ( IF 2.4 ) Pub Date : 2021-04-20 , DOI: 10.1121/10.0004218
Hamid Motallebzadeh 1 , Sunil Puria 1
Affiliation  

The mouse is an important animal model for hearing science. However, our knowledge of the relationship between mouse middle-ear (ME) anatomy and function is limited. The ME not only transmits sound to the cochlea in the forward direction, it also transmits otoacoustic emissions generated in the cochlea to the ear canal (EC) in the reverse direction. Due to experimental limitations, a complete characterization of the mouse ME has not been possible. A fully coupled finite-element model of the mouse EC, ME, and cochlea was developed and calibrated against experimental measurements. Impedances of the EC, ME, and cochlea were calculated, alongside pressure transfer functions for the forward, reverse, and round-trip directions. The effects on sound transmission of anatomical changes such as removing the ME cavity, pars flaccida, and mallear orbicular apophysis were also calculated. Surprisingly, below 10 kHz, the ME cavity, eardrum, and stapes annular ligament were found to significantly affect the cochlear input impedance, which is a result of acoustic coupling through the round window. The orbicular apophysis increases the delay of the transmission line formed by the flexible malleus, incus, and stapes, and improves the forward sound-transmission characteristics in the frequency region of 7–30 kHz.

中文翻译:

鼠标中耳正反向声学

小鼠是听力科学的重要动物模型。然而,我们对小鼠中耳 (ME) 解剖结构和功能之间关系的了解是有限的。ME 不仅将声音向前传输到耳蜗,它还将在耳蜗中产生的耳声发射反向传输到耳道 (EC)。由于实验限制,无法对鼠标 ME 进行完整表征。开发了小鼠 EC、ME 和耳蜗的完全耦合有限元模型,并根据实验测量值进行了校准。计算了 EC、ME 和耳蜗的阻抗,以及正向、反向和往返方向的压力传递函数。解剖学变化对声音传播的影响,例如去除 ME 腔、弛缓部、还计算了踝关节轮突。令人惊讶的是,在 10 kHz 以下,发现 ME 腔、鼓膜和镫骨环状韧带显着影响耳蜗输入阻抗,这是通过圆窗声耦合的结果。眼轮突增加了柔韧锤骨、砧骨和镫骨形成的传输线的延迟,改善了7-30 kHz频率范围内的前向传声特性。
更新日期:2021-04-20
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