Background The clinical and pathological risk factors for worse T stage and prognosis in eyelid and periocular squamous cell carcinomas (SCCs) remain unclear. P63 was reported to predict a worse prognosis in other SCCs; however, this correlation was not validated in eyelid and periocular SCCs. Methods We reported on a retrospective case series of 85 consecutive patients with eyelid and periocular SCCs from 1995 to 2019. Cox proportional hazards regression models and logistic regression models were applied for risk factor analysis. Results Thirty-nine (45.8%) patients were diagnosed with T4 SCCs. Four (5.1%) patients developed nodal metastasis, and five (6.4%) patients developed distant metastasis during the follow-up. 2-year and 5-year disease-specific survival rates were 95.3% and 86.4%, respectively. Poorly or moderately differentiated eyelid and periocular SCCs were associated with worse T stage (p=0.001; p=0.008). Poor differentiation was associated with a higher risk of recurrence (p=0.024). Disease-specific death was more common in patients with T4 stage SCCs (p=0.038, HR=9.05). P63 expression was more common in patients with T3c or worse stage (p=0.008, OR=3.77). P63 expression alone was associated with worse differentiation (p=0.029), higher risk of perineural invasion (p=0.042, OR=4.61) and metastasis (p=0.009, HR=3.99). P63 expression (p=0.012, HR=7.80), coexpression of P63 and Ki67 (p=0.007, HR=9.21) and distant metastasis (p=0.001, HR=11.23) were associated with disease-specific death. Conclusion Patients presented with more aggressive orbital invasion features and a higher rate of distant metastasis in this cohort. P63 and coexpression of Ki67 predicted a worse stage, differentiation and prognosis, including metastasis and death due to disease. Data are available on reasonable request. The datasets used and analysed during the current study are available from the corresponding authors on reasonable request.

中文翻译：

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眼睑和眼周鳞状细胞癌恶化分期和死亡率的临床和病理危险因素

背景 眼睑和眼周鳞状细胞癌 (SCC) T 分期恶化和预后的临床和病理危险因素仍不清楚。据报道，P63 可预测其他 SCC 的较差预后；然而，这种相关性并未在眼睑和眼周 SCC 中得到验证。方法 我们报告了 1995 年至 2019 年连续 85 例眼睑和眼周 SCC 患者的回顾性病例系列。应用 Cox 比例风险回归模型和逻辑回归模型进行危险因素分析。结果 39 例 (45.8%) 患者被诊断为 T4 SCC。随访期间，4名（5.1%）患者出现淋巴结转移，5名（6.4%）患者出现远处转移。2 年和 5 年疾病特异性生存率分别为 95.3% 和 86.4%。差或中度分化的眼睑和眼周 SCC 与较差的 T 分期相关（p=0.001；p=0.008）。分化差与较高的复发风险相关（p=0.024）。疾病特异性死亡在 T4 期 SCC 患者中更为常见（p=0.038，HR=9.05）。P63 表达在 T3c 或更差阶段的患者中更常见（p=0.008，OR=3.77）。单独的 P63 表达与较差的分化 (p=0.029)、较高的神经周围侵袭风险 (p=0.042, OR=4.61) 和转移 (p=0.009, HR=3.99) 相关。P63 表达 (p=0.012, HR=7.80)、P63 和 Ki67 的共表达 (p=0.007, HR=9.21) 和远处转移 (p=0.001, HR=11.23) 与疾病特异性死亡相关。结论 在该队列中，患者表现出更具侵袭性的眼眶侵犯特征和更高的远处转移率。P63 和 Ki67 的共表达预测更差的分期、分化和预后，包括疾病引起的转移和死亡。可根据合理要求提供数据。当前研究期间使用和分析的数据集可根据合理要求从相应的作者处获得。