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White matter microstructure associations with episodic memory in adults with Down syndrome: a tract-based spatial statistics study
Journal of Neurodevelopmental Disorders ( IF 4.9 ) Pub Date : 2021-04-20 , DOI: 10.1186/s11689-021-09366-1
Austin Bazydlo 1 , Matthew Zammit 1 , Minjie Wu 2 , Douglas Dean 1, 3 , Sterling Johnson 1, 3, 4 , Dana Tudorascu 2 , Ann Cohen 2 , Karly Cody 1 , Beau Ances 5 , Charles Laymon 2 , William Klunk 2 , Shahid Zaman 6 , Benjamin Handen 2 , Andrew Alexander 1, 4 , Bradley Christian 1, 3, 4 , Sigan Hartley 4, 7
Affiliation  

Nearly all persons with Down syndrome will show pathology of Alzheimer’s disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheimer’s disease in the Down syndrome population and understand the relationship of these biomarkers to cognitive symptoms in order to inform clinical trials. Although Alzheimer’s disease is often considered a disease of gray matter, white matter degeneration has been documented during the preclinical stage of Alzheimer’s disease. The current study examined the association between diffusion tensor imaging (DTI) measures of white matter microstructure and episodic memory performance in 52 adults with Down syndrome. Seventy (N = 70) participants (M = 40.13, SD = 7.77 years) received baseline scans as part of the Neurodegeneration in Aging Down Syndrome (NiAD) study at two imaging facilities (36 at the University of Wisconsin-Madison [UW-Madison] and 34 at the University of Pittsburgh Medical Center [UPMC]). All participants had genetically confirmed trisomy 21. Fifty-two (N = 52) participants remained after QC. The DTI measures, fractional anisotropy (FA) and mean diffusivity (MD), were calculated for each participant. A combined measure of episodic memory was generated by summing the z-scores of (1) Free and Cued Recall test and (2) Rivermead Behavioural Memory Test for Children Picture Recognition. The DTI data were projected onto a population-derived FA skeleton and tract-based spatial statistics analysis was conducted using the FSL tool PALM to calculate Pearson’s r values between FA and MD with episodic memory. A positive correlation of episodic memory with FA and a negative correlation of episodic memory and MD in the major association white matter tracts were observed. Results were significant (p < 0.05) after correction for chronological age, imaging site, and premorbid cognitive ability. These findings suggest that white matter degeneration may be implicated in early episodic memory declines prior to the onset of dementia in adults with Down syndrome. Further, our findings suggest a coupling of episodic memory and white matter microstructure independent of chronological age.

中文翻译:

唐氏综合症成人白质微结构与情景记忆的关联:基于束的空间统计研究

几乎所有患有唐氏综合症的人都会在 40 多岁时表现出阿尔茨海默病的病理特征。迫切需要研究确定唐氏综合症人群中阿尔茨海默病这些各种病理变化的早期生物标志物,并了解这些生物标志物与认知症状的关系,以便为临床试验提供信息。尽管阿尔茨海默病通常被认为是一种灰质疾病,但在阿尔茨海默病的临床前阶段已经记录了白质变性。目前的研究检查了 52 名患有唐氏综合症的成年人的白质微结构的扩散张量成像 (DTI) 测量与情景记忆表现之间的关联。七十 (N = 70) 名参与者 (M = 40.13, SD = 7。77 岁)在两个成像设施(威斯康星大学麦迪逊分校 [UW-麦迪逊分校] 36 个和匹兹堡大学医学中心 [UPMC] 34 个)接受了基线扫描,作为衰老唐氏综合症 (NiAD) 研究的一部分。 . 所有参与者都有基因证实的 21 三体。五十二名 (N = 52) 参与者在 QC 后仍然存在。计算每个参与者的 DTI 测量值、分数各向异性 (FA) 和平均扩散率 (MD)。通过将 (1) 自由和线索回忆测试和 (2) Rivermead 儿童图片识别行为记忆测试的 z 分数相加,生成了情景记忆的组合测量值。将 DTI 数据投影到人口衍生的 FA 骨架上,并使用 FSL 工具 PALM 进行基于区域的空间统计分析,以计算 FA 和 MD 之间的 Pearson r 值和情景记忆。观察到主要关联白质束中的情景记忆与 FA 呈正相关,而情景记忆与 MD 呈负相关。在对实际年龄、成像部位和病前认知能力进行校正后,结果显着(p < 0.05)。这些研究结果表明,白质变性可能与唐氏综合症成人痴呆发作之前的早期情景记忆衰退有关。此外,我们的研究结果表明情节记忆和白质微观结构的耦合与实际年龄无关。观察到主要关联白质束中的情景记忆与 FA 呈正相关,而情景记忆与 MD 呈负相关。在对实际年龄、成像部位和病前认知能力进行校正后,结果显着(p < 0.05)。这些研究结果表明,白质变性可能与唐氏综合症成人痴呆发作之前的早期情景记忆衰退有关。此外,我们的研究结果表明情节记忆和白质微观结构的耦合与实际年龄无关。观察到主要关联白质束中的情景记忆与 FA 呈正相关,而情景记忆与 MD 呈负相关。在对实际年龄、成像部位和病前认知能力进行校正后,结果显着(p < 0.05)。这些研究结果表明,白质变性可能与唐氏综合症成人痴呆发作之前的早期情景记忆衰退有关。此外,我们的研究结果表明情节记忆和白质微观结构的耦合与实际年龄无关。这些研究结果表明,白质变性可能与唐氏综合症成人痴呆发作之前的早期情景记忆衰退有关。此外,我们的研究结果表明情节记忆和白质微观结构的耦合与实际年龄无关。这些研究结果表明,白质变性可能与唐氏综合症成人痴呆发作之前的早期情景记忆衰退有关。此外,我们的研究结果表明情节记忆和白质微观结构的耦合与实际年龄无关。
更新日期:2021-04-20
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