In this work, a novel C(sp 3 )–C(sp 2 ) cross-dehydrogenative-coupling method is developed to react benzoxazin-2-one derivatives with various indoles. As a result, combined use of ball milling and Fe( ii ) catalysis leads to rapid coupling of 1,4-benzoxazinones with derivatives of indole. Under the conditions, derivatives of 1 couple with various indoles at room temperature to produce good yields of the desired compounds within 0.5–2 h time period. Thus, derivatives of both starting materials couple smoothly under relatively mild conditions to give good yields of 3 .

中文翻译：

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球磨和Fe（ii）催化协同促进1,4-苯并恶嗪酮与吲哚的交叉脱氢偶联

在这项工作中，开发了一种新颖的C（sp 3）–C（sp 2）交叉脱氢偶联方法，以使苯并恶嗪-2-酮衍生物与各种吲哚反应。结果，球磨和Fe（ii）催化的组合使用导致1，4-苯并恶嗪酮与吲哚的衍生物快速偶联。在这种条件下，室温下1的衍生物与各种吲哚偶合，可在0.5–2 h的时间内产生所需化合物的良好收率。因此，两种起始材料的衍生物在相对温和的条件下均能平滑偶联，从而获得3的良好产率。