Abstract

The ever-increasing biomedical application of magnetic nanoparticles (MNPs) implies increasing demand in their scalable and high-throughput production, with finely tuned and well-controlled characteristics. One of the options to meet the demand is microbial production by nanoparticles-synthesizing bacteria. This approach has several benefits over the standard chemical synthesis methods, including improved homogeneity of synthesis, cost-effectiveness, safety and eco-friendliness. There are, however, specific challenges emanating from the nature of the approach that are to be accounted and resolved in each manufacturing instance. Most of the challenges can be resolved by proper selection of the producing organism and optimizing cell culture and nanoparticles extraction conditions. Other issues require development of proper continuous production equipment, medium usage optimization and precursor ions recycling. This mini-review focuses on the related topics in microbial synthesis of MNPs: producing organisms, culturing methods, nanoparticles characteristics tuning, nanoparticles yield and synthesis timeframe considerations, nanoparticles isolation as well as on the respective challenges and possible solutions.

中文翻译：

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基于微生物的磁性纳米粒子生产：小型回顾

摘要

磁性纳米粒子 (MNP) 不断增加的生物医学应用意味着对其可扩展和高通量生产的需求不断增加，具有微调和良好控制的特性。满足需求的一种选择是通过纳米粒子合成细菌进行微生物生产。与标准化学合成方法相比，这种方法有几个好处，包括提高合成的均质性、成本效益、安全性和生态友好性。然而，在每个制造实例中都需要考虑和解决方法的性质所产生的具体挑战。Most of the challenges can be resolved by proper selection of the producing organism and optimizing cell culture and nanoparticles extraction conditions. 其他问题需要开发适当的连续生产设备、介质使用优化和前体离子回收。这篇小型评论侧重于 MNPs 微生物合成的相关主题：生产生物体、培养方法、纳米粒子特性调整、纳米粒子产量和合成时间框架考虑、纳米粒子分离以及各自的挑战和可能的解决方案。