Objectives

Parkinson's disease (PD) is the most common degenerative cause of movement disorder, and autonomic dysfunction has been recognized in this disorder. PD patients' lower urinary tract (LUT) function is not established. We investigated LUT function in PD by single-photon emission computerized tomography (SPECT) imaging of the dopamine transporter with ¹²³I-ioflupane and clinical-urodynamic observations.

Patients and methods

We retrospectively analyzed the cases of 30 patients diagnosed with PD based on published criteria who completed a systematized lower urinary tract symptoms (LUTS) questionnaire and a urodynamics examination irrespective of the presence of LUTS. None of the patients were taking anti-parkinsonian medication during the study.

Results

The questionnaire revealed that all 30 patients had LUTS: night-time urinary frequency (in 70%), urinary incontinence (40%), and daytime urinary frequency (80%). A urodynamic study revealed a mean volume at the first sensation at 92.3 ml, bladder capacity at 200.9 ml, and detrusor overactivity in 50%. Sphincter electromyography revealed neurogenic change in 13.6% of those for whom the test was performed. The average SBR showed a significant correlation with bladder capacity (Spearman's correlation coefficient p = 0.0076) and Hoehn Yahr motor stage (Spearman's correlation coefficient p = 0.012).

Conclusion

Our findings demonstrate that the striatum is relevant to the higher control of storage in micturition function in PD.

中文翻译：

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未用药帕金森病患者下尿路功能与123碘氟烷显像的关系

目标

帕金森病 (PD) 是运动障碍最常见的退行性病因，在这种疾病中已经认识到自主神经功能障碍。PD 患者的下尿路 (LUT) 功能尚未建立。我们通过多巴胺转运蛋白的单光子发射计算机断层扫描 (SPECT) 成像与¹²³ I-碘氟烷和临床尿动力学观察研究了 PD 中的 LUT 功能。

患者和方法

我们根据已发布的标准对 30 名诊断为 PD 的患者进行了回顾性分析，他们完成了系统化的下尿路症状 (LUTS) 问卷调查和尿动力学检查，无论是否存在 LUTS。在研究期间，没有患者服用抗帕金森病药物。

结果

问卷显示所有 30 名患者都有 LUTS：夜间尿频（70%）、尿失禁（40%）和白天尿频（80%）。尿动力学研究显示第一感觉时的平均容量为 92.3 毫升，膀胱容量为 200.9 毫升，逼尿肌过度活跃率为 50%。括约肌肌电图显示 13.6% 的接受测试者出现神经源性改变。平均 SBR 与膀胱容量（Spearman 相关系数 p = 0.0076）和 Hoehn Yahr 运动阶段（Spearman 相关系数 p = 0.012）显着相关。

结论

我们的研究结果表明，纹状体与 PD 排尿功能中存储的更高控制有关。