ABSTRACT

Superparamagnetic Fe₃O₄ has created major attention towards the drug delivery applications because it is used as the nanocarrier for delivering drugs to the specific tumour site and has less toxicity. The present report reveals a pH-responsive superparamagnetic iron oxide (Fe₃O₄) nanoparticle comprising with Polyethylene glycol-polymethyl methacrylate (PEG-PMMA) as a drug carrier. This magnetite nanoparticle is prepared by the hydrothermal method and characterized. The synthesised nanoparticles are uneven morphology in shape and with varying in diameter range of 30−150 nm. . In vitro curcumin loading and its releasing behaviour of magnetic nanoparticles were analysed using a UV-Vis spectrophotometer. The obtained result shows that curcumin was liberated in a well sustained manner particularly in the pH 5.4, which is well suited for a human body for delivering drugs. The synthesised nanomaterials were treated against adenocarcinoma gastric cell line (AGS). Cur-PEG-PMMA-Fe3O4 persistently repressed the progress of AGS cells in a dose and time-dependent manner.

摘要

超顺磁性Fe ₃ O ₄引起了人们对药物输送应用的极大关注，因为它用作将药物输送到特定肿瘤部位的纳米载体并且毒性较小。本报告揭示了一种包含聚乙二醇-聚甲基丙烯酸甲酯 (PEG-PMMA) 作为药物载体的 pH 响应超顺磁性氧化铁 (Fe ₃ O _{4 ) 纳米颗粒。}该磁铁矿纳米颗粒是通过水热法制备并表征的。合成的纳米颗粒在形状上是不均匀的，直径在 30-150 nm 范围内变化。. 体外使用紫外-可见分光光度计分析姜黄素负载及其磁性纳米粒子的释放行为。所得结果表明姜黄素以良好持续的方式释放，特别是在 pH 5.4 时，非常适合人体输送药物。合成的纳米材料被处理以对抗腺癌细胞系（AGS）。Cur-PEG-PMMA-Fe3O4 以剂量和时间依赖性方式持续抑制 AGS 细胞的进程。