Regulator of calcineurin 1 (RCAN1) is an endogenous protein that is involved in the regulation of the occurrence and progression of a variety of cancers, but currently, people know little about its potential mechanism. This study investigated the function and mechanism of RCAN1 and miR-182-5p in liver cancer cells. In this study, reliable data demonstrated that RCAN1 suppressed cell proliferation, migration, invasion, and cell cycle progression of liver cancer. Additionally, the expression of RCAN1 was noted to be regulated by its upstream regulator miR-182-5p, and miR-182-5p was prominently highly expressed in liver cancer cells. Based on this, it was further proved through cell experiments that miR-182-5p facilitated cell growth of liver cancer through RCAN1 downregulation, showing that RCAN1 may be a fresh biomarker and target for diagnosis and treatment of liver cancer.

中文翻译：

---

mir-182-5p通过靶向RCAN1调节肝癌的细胞生长

钙调神经磷酸酶1（RCAN1）的调节剂是一种内源性蛋白质，参与多种癌症的发生和发展调控，但目前，人们对其潜在机制了解甚少。这项研究调查了RCAN1和miR-182-5p在肝癌细胞中的功能和机制。在这项研究中，可靠的数据表明RCAN1抑制肝癌的细胞增殖，迁移，侵袭和细胞周期进程。此外，RCAN1的表达受到上游调节物miR-182-5p的调节，而miR-182-5p在肝癌细胞中的表达也很显着。在此基础上，通过细胞实验进一步证明miR-182-5p通过RCAN1下调促进了肝癌细胞的生长，