SARS-CoV-2, the leading cause of COVID-19 pandemic, was detected for the first time in Wuhan. In this study, we investigated the potential undesirable maternal and feto-neonatal consequences of COVID-19, and the related pathophysiological alterations in mother, neonate, and especially in the placenta as a vital organ, were reviewed. Also, the possibility of vertical transmission of virus and placental abnormalities were evaluated. The pregnant women were a vulnerable population for COVID-19, and several obstetric consequences were reported following SARS-CoV-2 infection. The higher risk of abruption, preterm labor, maternal death, stillbirth, intrauterine growth restriction, and newborns with fetal distress were adverse pregnancy and perinatal outcomes of COVID-19. Despite the ACE2 expression on placental components was confirmed, there is no agreement on the mother–child vertical transmission of this virus. Therefore, feto-neonatal consequences might be associated with placental abnormalities. The placental abnormalities are characterized by feto-maternal vascular malperfusion. Additionally, these adverse consequences lead to early termination of pregnancy in some cases, mostly via cesarean section. The pregnant women screening, coordination between healthcare personnel and neonatal unit, and infected women quarantine may decrease the risk of maternal and neonatal death after delivery.

SARS-CoV-2 是导致 COVID-19 大流行的主要原因，在武汉首次被发现。在这项研究中，我们调查了 COVID-19 对母体和胎儿新生儿的潜在不良后果，并回顾了母亲、新生儿，尤其是作为重要器官的胎盘的相关病理生理变化。此外，还评估了病毒垂直传播和胎盘异常的可能性。孕妇是 COVID-19 的易感人群，据报道感染 SARS-CoV-2 后会产生多种产科后果。早产、早产、产妇死亡、死产、宫内生长受限和胎儿窘迫的新生儿风险较高是 COVID-19 的不良妊娠和围产期结局。尽管证实了胎盘成分上的 ACE2 表达，关于这种病毒的母婴垂直传播尚无共识。因此，胎儿-新生儿后果可能与胎盘异常有关。胎盘异常以胎儿-母体血管灌注不良为特征。此外，这些不良后果在某些情况下会导致提前终止妊娠，主要是通过剖宫产。孕妇筛查、医护人员与新生儿科的协调、感染妇女隔离等，可降低孕产妇和新生儿产后死亡的风险。在某些情况下，这些不良后果导致提前终止妊娠，主要是通过剖宫产。孕妇筛查、医护人员与新生儿科的协调、感染妇女隔离等，可降低孕产妇和新生儿产后死亡的风险。在某些情况下，这些不良后果导致提前终止妊娠，主要是通过剖宫产。孕妇筛查、医护人员与新生儿科的协调、感染妇女隔离等，可降低孕产妇和新生儿产后死亡的风险。