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Normal and reference values for cardiovascular magnetic resonance-based pulse wave velocity in the middle-aged general population
Journal of Cardiovascular Magnetic Resonance ( IF 6.4 ) Pub Date : 2021-04-19 , DOI: 10.1186/s12968-021-00739-y
Max J van Hout 1 , Ilona A Dekkers 2 , Jos J Westenberg 2 , Martin J Schalij 1 , Ralph L Widya 2 , Renée de Mutsert 3 , Frits R Rosendaal 3 , Albert de Roos 2 , J Wouter Jukema 1 , Arthur J Scholte 1 , Hildo J Lamb 2
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Aortic stiffness, assessed through pulse wave velocity (PWV), is an independent predictor for cardiovascular disease risk. However, the scarce availability of normal and reference values for cardiovascular magnetic resonance imaging (CMR) based PWV is limiting clinical implementation. The aim of this study was to determine normal and reference values for CMR assessed PWV in the general population. From the 2,484 participants of the Netherlands Epidemiology of Obesity (NEO) study that have available CMR-PWV data, 1,394 participants free from cardiovasculard disease, smokers or treatment for diabetes, hypertension or dyslipidaemia were selected (45–65 years, 51% female). Participants were divided into sex, age and blood pressure (BP) subgroups. Normal values were specified for participants with a BP < 130/80 mmHg and reference values for elevated BP subgroups (≥ 130/80 and < 140/90 mmHg; and ≥ 140/90 mmHg). Differences between groups were tested with independent samples t-test or ANOVA. Due to an oversampling of obese individuals in this study, PWV values are based on a weighted analysis making them representative of the general population. Normal mean PWV was 6.0 m/s [95% CI 5.8–6.1]. PWV increased with advancing age and BP categories (both p < 0.001). There was no difference between sex in normal PWV, however in the BP > 140/90 mmHg women had a higher PWV (p = 0.005). The interpercentile ranges were smaller for participants < 55 years old compared to participants ≥ 55 years, indicating an increasing variability of PWV with age. PWV upper limits were particularly elevated in participants ≥ 55 years old in the high blood pressure subgroups. This study provides normal and reference values for CMR-assessed PWV per sex, age and blood pressure category in the general population.

中文翻译:

中年普通人群心血管磁共振脉搏波速度的正常值和参考值

通过脉搏波速度 (PWV) 评估的主动脉僵硬度是心血管疾病风险的独立预测因子。然而,基于心血管磁共振成像 (CMR) 的 PWV 的正常值和参考值的稀缺可用性限制了临床实施。本研究的目的是确定一般人群中 CMR 评估的 PWV 的正常值和参考值。从拥有 CMR-PWV 数据的荷兰肥胖流行病学 (NEO) 研究的 2,484 名参与者中,选择了 1,394 名没有心血管疾病、吸烟者或糖尿病、高血压或血脂异常治疗的参与者(45-65 岁,51% 为女性) . 参与者被分为性别、年龄和血压 (BP) 亚组。为 BP < 的参与者指定正常值 130/80 mmHg 和血压升高亚组的参考值(≥ 130/80 和 < 140/90 mmHg;和 ≥ 140/90 mmHg)。使用独立样本 t 检验或方差分析测试组间差异。由于本研究中对肥胖个体的过度抽样,PWV 值基于加权分析,使它们能够代表一般人群。正常平均 PWV 为 6.0 m/s [95% CI 5.8–6.1]。PWV 随着年龄和血压类别的增加而增加(均 p < 0.001)。正常 PWV 的性别之间没有差异,但是在 BP > 140/90 mmHg 时,女性的 PWV 较高(p = 0.005)。与 ≥ 55 岁的参与者相比,< 55 岁的参与者的百分位数范围更小,表明 PWV 的变异性随着年龄的增长而增加。PWV 上限在高血压亚组中≥ 55 岁的参与者中特别高。本研究提供了普通人群中按性别、年龄和血压类别计算的 CMR 评估 PWV 的正常值和参考值。
更新日期:2021-04-19
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