Thyroid cancer is a relatively common endocrine gland malignant tumor; if improper treatment, there will be a high risk of recurrence or metastasis, and abnormal sugar chain glycoprotein (TAP) has a close relationship with the development of the disease; therefore, the purpose of this article is to discuss abnormal sugar chain glycoprotein (TAP) as thyroid cancer curative effect evaluation and radiation and chemotherapy after surgery clinical significance. In this paper, 95 patients with thyroid cancer diagnosed in a hospital were selected as the study objects and treated as the observation group. The clinical and follow-up data of the observation group were retrospectively analyzed. Meanwhile, 55 healthy patients were randomly selected as the control group. TAP, squamous cell carcinoma antigen (SCC) level, and carcinoembryonic antigen (CEA) level were detected in peripheral blood of 95 patients with thyroid cancer before and after treatment. The short-term efficacy was evaluated by chest CT examination, and the changes of the three markers before and after treatment and the correlation with the short-term efficacy of the patients were compared. According to the results of testing, the TAP positive expression in patients before radiotherapy can better predict the recent curative effect has certain clinical value; before radiotherapy TAP positive expression rate was significantly higher than that of healthy people, TAP positive expression quantity decreased obviously after radiation treatment, and patients with a recent radiotherapy curative effect is good or bad and negatively correlated with the degree of TAP protein positive expression; TAP high protein in patients with recent poor radiation effects, prompt the factor can be predicted in the near future curative effect of the molecular markers, and can TAP level for clinicians provide certain reference for targeted therapy.

中文翻译：

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甲状腺癌术后及放化疗后TAP测试图像动态跟踪研究

甲状腺癌是较常见的内分泌腺恶性肿瘤；如果治疗不当，复发或转移的风险很高，而异常的糖链糖蛋白（TAP）与疾病的发展有着密切的关系；因此，本文的目的是探讨糖链糖蛋白异常（TAP）作为甲状腺癌疗效评价及术后放化疗的临床意义。本文选取某医院确诊的95例甲状腺癌患者作为研究对象，作为观察组。回顾性分析观察组的临床及随访资料。同时随机选取55名健康患者作为对照组。检测95例甲状腺癌患者治疗前后外周血中TAP、鳞状细胞癌抗原（SCC）水平、癌胚抗原（CEA）水平。通过胸部CT检查评价近期疗效，比较治疗前后三项标志物的变化以及与患者近期疗效的相关性。根据检测结果，患者放疗前TAP阳性表达可以较好地预测近期疗效，具有一定的临床价值；放疗前TAP蛋白阳性表达率显着高于健康人群，放疗后TAP阳性表达量明显下降，患者近期放疗疗效好坏与TAP蛋白阳性表达程度呈负相关；TAP高蛋白出现在近期放疗效果不佳的患者中，提示该因素是可以预测近期疗效的分子标志物，并且可以为临床医生的TAP水平进行靶向治疗提供一定的参考。