Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder,Bipolar Disorders

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Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder
Bipolar Disorders ( IF 5.4 ) Pub Date : 2021-04-17 , DOI: 10.1111/bdi.13081
Susannah J Tye _{1,

2,

3} , Kristin Borreggine ₁ , J Blair Price _{1,

3} , Shari L Sutor ₁ , Alfredo B Cuéllar-Barboza _{1,

4} , Susan L McElroy _{5,

6} , Joanna M Biernacka _{1,

7} , Mark A Frye ₁

Affiliation

A key mechanism of lithium is the inhibition of glycogen synthase kinase-3β (GSK3β) and activation of mammalian target of rapamycin (mTOR), two contributors to insulin signaling. We explored the relationship between these markers and clinical response to lithium in bipolar disorder (BD).

中文翻译：

外周免疫细胞中动态胰岛素刺激的 mTOR/GSK3 信号传导：与双相情感障碍中锂反应相关的初步证据

锂的一个关键机制是抑制糖原合酶激酶 3β (GSK3β) 和激活哺乳动物雷帕霉素靶蛋白 (mTOR)，这两个是胰岛素信号传导的贡献者。我们探讨了这些标志物与双相情感障碍 (BD) 中锂的临床反应之间的关系。

更新日期：2021-04-17

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