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Effect of preoxygenation before isoflurane induction and rocuronium-induced apnea on time until hemoglobin desaturation in domestic chickens (Gallus gallus domesticus)
Veterinary Anaesthesia and Analgesia ( IF 1.7 ) Pub Date : 2021-04-18 , DOI: 10.1016/j.vaa.2021.03.011
Crystalyn Legg-St Pierre 1 , Isabelle Desprez 1 , Stephanie Chang 2 , Karen Machin 3 , Barbara Ambros 1
Affiliation  

Objective

To evaluate the time to hemoglobin oxygen desaturation in chickens (Gallus gallus domesticus) with and without preoxygenation before isoflurane induction of anesthesia and rocuronium-induced apnea.

Study design

Prospective, randomized crossover study.

Animals

A total of 10 healthy adult Lohmann Brown-Lite hens.

Methods

Hens were anesthetized with isoflurane for intravenous (IV) and intraarterial catheter placement and allowed to fully recover from anesthesia. Hens in the preoxygenation treatment were administered oxygen (2 L minute–1) via a facemask for 3 minutes prior to induction of anesthesia with 3% isoflurane in oxygen. In the alternative treatment, hens were not preoxygenated prior to induction of anesthesia with isoflurane in oxygen. Apnea was then induced with rocuronium bromide (1.0 mg kg–1) administered IV, and anesthesia was maintained with IV propofol infusion. A cloacal pulse oximeter measured hemoglobin oxygen saturation (SpO2). Time was recorded from the start of apnea until SpO2 was 90% (desaturation). The trachea was intubated, and anesthesia was maintained with isoflurane in oxygen with manual ventilation until spontaneous breathing returned and SpO2 ≥ 99%. PaO2 was measured before each treatment, after preoxygenation, postinduction and at desaturation. Data were analyzed between treatments using Wilcoxon matched-pairs signed rank tests with Holm-Šidák multiple comparison test, and within treatments using Friedman test with Dunn’s multiple comparison test (p < 0.05). Data are reported as median (range).

Results

Time from start of apnea until hemoglobin desaturation was not significantly different between preoxygenated and nonpreoxygenated hens [26.5 (16–50) seconds and 24.0 (5–57) seconds, respectively; p = 0.25]. No differences in PaO2 between treatments were observed at any time point.

Conclusions and clinical relevance

Preoxygenation for 3 minutes before isoflurane mask induction of anesthesia and apnea does not significantly increase time until desaturation in hens.



中文翻译:

异氟醚诱导前预氧合和罗库溴铵诱导的呼吸暂停对家鸡(Gallus gallus domesticus)血红蛋白去饱和时间的影响

客观的

评估在异氟醚诱导麻醉和罗库溴铵诱导的呼吸暂停之前有和没有预氧合的鸡 ( Gallus gallus domesticus )血红蛋白氧饱和度下降的时间。

学习规划

前瞻性随机交叉研究。

动物

共有 10 只健康的成年 Lohmann Brown-Lite 母鸡。

方法

用异氟醚麻醉母鸡以进行静脉内 (IV) 和动脉内导管放置,并使其完全从麻醉中恢复。预氧合处理中的母鸡在使用 3% 异氟醚的氧气诱导麻醉前,通过面罩给予氧气(2 L 分钟–1分钟) 3 分钟。在替代治疗中,母鸡在用氧气中的异氟醚诱导麻醉之前没有进行预充氧。然后通过静脉注射罗库溴铵 (1.0 mg kg –1 ) 诱导呼吸暂停,并通过静脉输注丙泊酚维持麻醉。泄殖腔脉搏血氧仪测量血红蛋白氧饱和度 (SpO 2 )。记录从呼吸暂停开始到 SpO 2的时间为 90%(去饱和度)。气管插管,异氟醚氧合手动通气维持麻醉,直至自主呼吸恢复,SpO 2 ≥ 99%。在每次治疗前、预氧合后、诱导后和去饱和时测量PaO 2 。使用 Wilcoxon 配对符号秩检验和 Holm-Šidák 多重比较检验分析治疗之间的数据,以及使用 Dunn 多重比较检验的弗里德曼检验 ( p < 0.05)。数据报告为中值(范围)。

结果

从开始呼吸暂停到血红蛋白去饱和的时间在预氧合和非预氧合母鸡之间没有显着差异[分别为 26.5 (16-50) 秒和 24.0 (5-57) 秒;p  = 0.25]。在任何时间点均未观察到处理之间的 PaO 2差异。

结论和临床相关性

在异氟醚面罩诱导麻醉和呼吸暂停之前预氧合 3 分钟不会显着增加母鸡去饱和的时间。

更新日期:2021-06-23
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