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Development and optimization of multicolumn chromatography for mAb perfusion processes
Journal of Chemical Technology and Biotechnology ( IF 3.4 ) Pub Date : 2021-04-18 , DOI: 10.1002/jctb.6757
Keith Gillette 1 , Marc Bisschops 2 , Mark Schofield 1
Affiliation  

The maturation of the bioprocessing industry is driving the desire to reduce manufacturing costs through process intensification. Here we discuss the motivation for more productive upstream perfusion processes and the implications for downstream purification. The focus of the article is how to optimize the downstream process chromatography steps based on perfusion upstream. A range of different chromatography solutions are explored and their possible impact on the purification process discussed. © 2021 Society of Chemical Industry

中文翻译:

用于 mAb 灌注过程的多柱色谱的开发和优化

生物加工工业的成熟推动了通过工艺强化来降低制造成本的愿望。在这里,我们讨论了更高效的上游灌注过程的动机以及对下游纯化的影响。本文的重点是如何基于上游灌注优化下游工艺色谱步骤。探索了一系列不同的色谱解决方案,并讨论了它们对纯化过程的可能影响。© 2021 化学工业学会
更新日期:2021-04-18
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