Upon first glance at a bacterial genome, pseudoenzymes appear unremarkable due to their lack of critical motifs that facilitate catalysis. These pseudoenzymes exist within signal transduction enzymes including histidine kinases, response regulators, diguanylate cyclases, and phosphodiesterases. Here, we summarize recent studies of bacterial pseudo-histidine kinases and pseudo-response regulators that regulate cell division, capsule formation, and the circadian rhythm. These examples illuminate the mechanistic potential of catalytically dead signaling enzymes and their impact upon bacterial signal transduction. Moreover, proteins lacking characteristic catalytic features of two-component systems reveal the sophisticated underlying potential of canonical two-component systems.

乍一看细菌基因组，假酶由于缺乏促进催化的关键基序而显得不起眼。这些假酶存在于信号转导酶中，包括组氨酸激酶、反应调节剂、二鸟苷酸环化酶和磷酸二酯酶。在这里，我们总结了最近对调节细胞分裂、胶囊形成和昼夜节律的细菌假组氨酸激酶和假反应调节剂的研究。这些例子阐明了催化死亡信号酶的机械潜力及其对细菌信号转导的影响。此外，缺乏双组分系统特征催化特征的蛋白质揭示了经典双组分系统复杂的潜在潜力。