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Central Nervous System Manifestations of COVID-19: A Critical Review and Proposed Research Agenda
Journal of the International Neuropsychological Society ( IF 2.6 ) Pub Date : 2021-04-16 , DOI: 10.1017/s1355617721000345
Kelsey C Hewitt 1 , David E Marra 2 , Cady Block 1 , Lucette A Cysique 3, 4 , Daniel L Drane 1, 5 , Michelle M Haddad 6 , Emilia Łojek 7 , Carrie R McDonald 8 , Anny Reyes 8 , Kara Eversole 9 , Dawn Bowers 2
Affiliation  

Objective:

On March 11, 2020, the World Health Organization declared an outbreak of a new viral entity, coronavirus 2019 (COVID-19), to be a worldwide pandemic. The characteristics of this virus, as well as its short- and long-term implications, are not yet well understood. The objective of the current paper was to provide a critical review of the emerging literature on COVID-19 and its implications for neurological, neuropsychiatric, and cognitive functioning.

Method:

A critical review of recently published empirical research, case studies, and reviews pertaining to central nervous system (CNS) complications of COVID-19 was conducted by searching PubMed, PubMed Central, Google Scholar, and bioRxiv.

Results:

After considering the available literature, areas thought to be most pertinent to clinical and research neuropsychologists, including CNS manifestations, neurologic symptoms/syndromes, neuroimaging, and potential long-term implications of COVID-19 infection, were reviewed.

Conclusion:

Once thought to be merely a respiratory virus, the scientific and medical communities have realized COVID-19 to have broader effects on renal, vascular, and neurological body systems. The question of cognitive deficits is not yet well studied, but neuropsychologists will undoubtedly play an important role in the years to come.



中文翻译:

COVID-19 的中枢神经系统表现:批判性回顾和拟议的研究议程

客观的:

2020 年 3 月 11 日,世界卫生组织宣布新型病毒实体 2019 冠状病毒 (COVID-19) 的爆发为全球大流行。这种病毒的特征及其短期和长期影响尚不清楚。本文的目的是对有关 COVID-19 的新兴文献及其对神经学、神经精神病学和认知功能的影响进行批判性回顾。

方法:

通过搜索 PubMed、PubMed Central、Google Scholar 和 bioRxiv,对最近发表的有关 COVID-19 中枢神经系统 (CNS) 并发症的实证研究、案例研究和评论进行了严格审查。

结果:

在考虑现有文献后,对被认为与临床和研究神经心理学家最相关的领域进行了回顾,包括中枢神经系统表现、神经系统症状/综合征、神经影像学以及 COVID-19 感染的潜在长期影响。

结论:

科学界和医学界一度认为 COVID-19 只是一种呼吸道病毒,但现在已经意识到它对肾脏、血管和神经系统有更广泛的影响。认知缺陷问题尚未得到充分研究,但神经心理学家无疑将在未来几年发挥重要作用。

更新日期:2021-04-16
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