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Long-term Observation of Gastric Adenocarcinoma of Fundic Gland Mucosa Type before and after Helicobacter pylori Eradication: a Case Report.
Journal of Gastric Cancer ( IF 2.5 ) Pub Date : 2021-03-29 , DOI: 10.5230/jgc.2021.21.e11
Keitaro Takahashi 1 , Nobuhiro Ueno 1 , Takahiro Sasaki 1 , Yu Kobayashi 1 , Yuya Sugiyama 1 , Yuki Murakami 1 , Takehito Kunogi 1 , Katsuyoshi Ando 1 , Shin Kashima 1 , Kentaro Moriichi 1 , Hiroki Tanabe 1 , Yuki Kamikokura 2 , Sayaka Yuzawa 2 , Mishie Tanino 2 , Toshikatsu Okumura 1 , Mikihiro Fujiya 1
Affiliation  

Gastric adenocarcinoma of the fundic gland mucosa type (GA-FGM) was proposed as a new variant of gastric adenocarcinoma of the fundic gland type (GA-FG). However, at present, the influence of Helicobacter pylori and the speed of progression and degree of malignancy in GA-FGM remain unclear. Herein, we report the first case of intramucosal GA-FGM that was endoscopically observed before and after H. pylori eradication over 15 years. The lesion showed the same tumor size with no submucosal invasion and a low MIB-1 labeling index 15 years after its detection using endoscopy. The endoscopic morphology changed from 0-IIa before H. pylori eradication to 0-IIa+IIc and then 0-I after H. pylori eradication. These findings suggest that the unaltered tumor size reflects low-grade malignancy and slow growth, and that the endoscopic morphology is influenced by H. pylori eradication.

中文翻译:

根除幽门螺杆菌前后胃底黏膜类型胃腺癌的长期观察:病例报告。

提出了胃腺黏膜类型(GA-FGM)的胃腺癌作为胃腺类型(GA-FG)的胃腺癌的新变体。然而,目前,尚不清楚幽门螺杆菌在GA-FGM中的影响以及进展速度和恶性程度。在此,我们报道了在15年内根除幽门螺杆菌之前和之后在内窥镜下观察到的第一例粘膜内GA-FGM 。使用内窥镜检查发现病变15年后,病变显示相同的肿瘤大小,没有粘膜下浸润,MIB-1标记指数低。内镜形态从幽门螺杆菌根除之前的0-IIa变为0-IIa + IIc,然后从幽门螺杆菌之后变为0-I 根除。这些发现表明未改变的肿瘤大小反映了低度恶性肿瘤和缓慢的生长,并且内窥镜形态受到幽门螺杆菌根除的影响。
更新日期:2021-04-17
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