Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease,Journal of Neuropathology and Experimental Neurology

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Asymmetry of Hippocampal Tau Pathology in Primary Age-Related Tauopathy and Alzheimer Disease
Journal of Neuropathology and Experimental Neurology ( IF 3.2 ) Pub Date : 2021-04-17 , DOI: 10.1093/jnen/nlab032
Jamie M Walker _{1,

2} , Yelena Fudym _{3,

4} , Kurt Farrell _{5,

6,

7} , Megan A Iida _{5,

6,

7,

8} , Kevin F Bieniek _{1,

2,

9} , Sudha Seshadri _{2,

10,

11} , Charles L White ₁₂ , John F Crary _{5,

6,

7} , Timothy E Richardson _{1,

2,

3}

Affiliation

From the Department of Pathology and Laboratory Medicine, Upstate Medical University, Syracuse, New York, USA.
Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Science Center, San Antonio, Texas, USA.
Department of Pathology, State University of New York, Upstate Medical University, Syracuse, New York, USA.
Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA.
Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ronald M. Loeb Center for Alzheimer's Disease, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
School of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA.
Department of Neurology, University of Texas Health Science Center, San Antonio, Texas, USA.
The Framingham Heart Study, Framingham, Massachusetts, USA.
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Primary age-related tauopathy (PART) is a neurodegenerative entity defined as neurofibrillary degeneration generally restricted to the medial temporal region (Braak stage I–IV) with complete or near absence of diffuse and neuritic plaques. Symptoms range in severity but are generally milder and later in onset than in Alzheimer disease (AD). Recently, an early predilection for neurofibrillary degeneration in the hippocampal CA2 subregion has been demonstrated in PART, whereas AD neuropathologic change (ADNC) typically displays relative sparing of CA2 until later stages. In this study, we utilized a semiquantitative scoring system to evaluate asymmetry of neurofibrillary degeneration between left and right hippocampi in 67 PART cases and 17 ADNC cases. 49% of PART cases demonstrated asymmetric findings in at least one hippocampal subregion, and 79% of the asymmetric cases displayed some degree of CA2 asymmetry. Additionally, 19% of cases revealed a difference in Braak score between the right and left hippocampi. There was a significant difference in CA2 neurofibrillary degeneration (p = 0.0006) and CA2/CA1 ratio (p < 0.0001) when comparing the contralateral sides, but neither right nor left was more consistently affected. These data show the importance of analyzing bilateral hippocampi in the diagnostic evaluation of PART and potentially of other neurodegenerative diseases.

中文翻译：

海马 Tau 病理在原发性年龄相关性 Tauopathy 和阿尔茨海默病中的不对称性

原发性年龄相关性 tauopathy (PART) 是一种神经退行性疾病，定义为神经原纤维变性，通常局限于内侧颞区（Braak I-IV 期），完全或几乎没有弥漫性和神经炎斑块。症状的严重程度不等，但通常比阿尔茨海默病 (AD) 更轻微且发病时间更晚。最近，在 PART 中证实了海马 CA2 亚区神经原纤维变性的早期偏好，而 AD 神经病理学变化 (ADNC) 通常显示 CA2 相对保留直到后期。在这项研究中，我们使用半定量评分系统来评估 67 例 PART 病例和 17 例 ADNC 病例中左右海马神经原纤维变性的不对称性。49% 的 PART 病例在至少一个海马亚区表现出不对称的表现，79% 的不对称病例表现出某种程度的 CA2 不对称。此外，19% 的病例显示左右海马的 Braak 评分存在差异。比较对侧时，CA2 神经原纤维变性 (p = 0.0006) 和 CA2/CA1 比率 (p < 0.0001) 存在显着差异，但右侧和左侧均未受到更一致的影响。这些数据表明分析双侧海马在 PART 和其他神经退行性疾病的诊断评估中的重要性。0001) 比较对侧时，但左右两侧均未受到更一致的影响。这些数据表明分析双侧海马在 PART 和其他神经退行性疾病的诊断评估中的重要性。0001) 比较对侧时，但左右两侧均未受到更一致的影响。这些数据表明分析双侧海马在 PART 和其他神经退行性疾病的诊断评估中的重要性。

更新日期：2021-04-17

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