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Diterpenoid Alkaloids from the Aerial Parts of Aconitum flavum Hand.-Mazz
Natural Products and Bioprospecting Pub Date : 2021-04-16 , DOI: 10.1007/s13659-021-00302-3
Na Zhang 1, 2 , Fan Xia 1 , Song-Yu Li 1, 2 , Yin Nian 1 , Li-Xin Wei 3 , Gang Xu 1
Affiliation  

Sixteen diterpenoid alkaloids (DAs), including six aconitine-type alkaloids (5 and 9 − 13), seven 7,17-seco-aconitine-type alkaloids (1 − 4, 6 − 8), two napelline-type alkaloids (14 and 15) as well as one veatchine-type alkaloid (16), were isolated from the aerial parts of Aconitum flavum Hand.-Mazz. In which, flavumolines A − D (1 − 4) were four new ones, and flavumoline E (5) was reported as natural compound for the first time. Their chemical structures were elucidated by the analysis of extensive spectroscopic data. The inhibitory activities of these isolates on Cav3.1 low voltage-gated Ca2+ channel, NO production in LPS-activated RAW264.7cells, five human tumor cell lines, as well as acetylcholinesterase (AChE) were tested.



中文翻译:

黄乌头地上部分的二萜生物碱。-Mazz

十六种二萜生物碱(DA),包括六种乌头碱型生物碱(59  −  13)、七种 7,17-仲乌头碱型生物碱(1  −  46  −  8)、两种乌头碱型生物碱(1415 ) 以及一种veatchine 型生物碱( 16 ) 是从Aconitum flavum Hand.-Mazz的地上部分中分离出来的。其中,黄酮素A−D(  1−4  )为4个新化合物,黄酮素E( 5 )为首次作为天然化合物报道。通过分析大量的光谱数据阐明了它们的化学结构。测试了这些分离株对 Ca v 3.1 低压门控 Ca 2+通道、LPS 激活的 RAW264.7 细胞、五种人类肿瘤细胞系以及乙酰胆碱酯酶 (AChE) 中 NO 产生的抑制活性。

更新日期:2021-04-16
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