Bladder pain syndrome (BPS) is a debilitating disease in humans, particularly women, with patients experiencing chronic, intractable, lower urinary and pelvic pain. Although rodent models have been used, feline idiopathic cystitis (FIC) is a naturally occurring bladder disease of cats that is frequently considered to be the preferred model for BPS. Histologically, FIC is most similar to the non-Hunner BPS subtype. Histology is unnecessary for the clinical diagnosis of FIC but is of great value in elucidating the pathogenesis of this disease so that prevention and therapeutic interventions can be optimized. Further study of the histological features of FIC and BPS is required to determine the significance of Von Brunn's nests, which are invaginations of hyperplastic urothelium that have been associated with irritative bladder stimuli in animals and have been observed in FIC. We review the possible pathogenesis, histopathological similarities and differences between FIC and BPS, and highlight the potential of FIC as a model of BPS.

膀胱疼痛综合征 (BPS) 是一种使人类（尤其是女性）衰弱的疾病，患者会经历慢性、顽固性、下尿路和盆腔疼痛。尽管已使用啮齿动物模型，但猫特发性膀胱炎 (FIC) 是一种自然发生的猫膀胱疾病，通常被认为是 BPS 的首选模型。在组织学上，FIC 与非 Hunner BPS 亚型最相似。组织学对于 FIC 的临床诊断是不必要的，但对于阐明该疾病的发病机制具有重要价值，从而可以优化预防和治疗干预措施。需要进一步研究 FIC 和 BPS 的组织学特征以确定 Von Brunn 巢的重要性，这是增生性尿路上皮的内陷，与动物刺激性膀胱刺激有关，并已在 FIC 中观察到。我们回顾了 FIC 和 BPS 之间可能的发病机制、组织病理学的异同，并强调了 FIC 作为 BPS 模型的潜力。