Purpose: We aimed to find out the distributed functional connectome of white matter in patients with functional dyspepsia (FD). Methods: 20 patients with FD and 24 age- and gender-matched healthy controls were included into the study. The functional connectome of white matter and graph theory were used to these participants. Two sample T test was used for the detection the abnormal graph properties in FD. Pearson correlation was used for the relationship between properties and information of clinical and neuropshychological. Results: patients with FD and healthy controls showed small-world properties in functional connectome of white matter. Compared to healthy controls, the FD group showed decreased global properties(Cp, S, Eglobal, Elocal). Four pairs of fiber bundles who connected to frontal lobe, insula and thalamus were affected in FD group. Duration and Pittsburgh Sleep Quality Index (PSQI) positive correlated with the betweenness centrality of white matter ROIs. Conclusion: FD patients turned to a non-optimized functional organization of WM brain network. Frontal lobe, insula and thalamus were key regions in brain information exchange of FD. It provided some novel imaging evidences for the mechanism of FD.

中文翻译：

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功能性消化不良患者的白色物质分布式功能性连接体

目的：我们旨在找出功能性消化不良（FD）患者中白质分布的功能性连接体。方法：将20名FD患者和24名年龄和性别相匹配的健康对照纳入研究。这些参与者使用了白质的功能性连接体和图论。两次样品T检验用于检测FD中的异常图形特性。皮尔逊相关性用于临床和神经心理学的特性与信息之间的关系。结果：FD患者和健康对照者在功能性白质连接体中显示出小世界特征。与健康对照组相比，FD组表现出整体特性（Cp，S，Eglobal，Elocal）下降。FD组有四对与额叶，岛状和丘脑相连的纤维束受到影响。持续时间和匹兹堡睡眠质量指数（PSQI）与白质ROI的中间性正相关。结论：FD患者转向WM脑网络的非最佳功能组织。额叶，岛状和丘脑是FD大脑信息交换的关键区域。它为FD的机制提供了一些新颖的影像学证据。