There are suggestions that sugars in diet can play a role in vulnerability to opioid abuse. The current study examined a range of neuro-behavioural interactions between oxycodone (OXY) and high fructose corn syrup (HFCS). Male Sprague-Dawley rats had access to HFCS (0 or 50%) over 26 days in their home cages and they were tested on place conditioning induced by 0, 0.16 and 2.5 mg/kg OXY (3 pairings of drug and saline, each 30 min), as well as on locomotor responses to 0, 0.16 and 2.5 mg/kg OXY, and in-vivo microdialysis was employed to measure dopamine (DA) levels in the nucleus accumbens (NAc) in response to 0 and 2.5 mg/kg OXY. A complex set of interactions between HFCS exposure and responses to OXY were observed: HFCS increased place preference induced by OXY, it enhanced the suppressant effect of OXY on locomotion, and it attenuated OXY-induced elevation in DA overflow in the NAc. Taken together, these findings suggest that nutrition has the potential to influence some responses to opioids which may be relevant to their abuse.

有建议表明，饮食中的糖分可能会导致阿片类药物滥用的脆弱性。目前的研究检查了羟考酮 (OXY) 和高果糖玉米糖浆 (HFCS) 之间的一系列神经行为相互作用。雄性 Sprague-Dawley 大鼠在其家笼中 26 天内可以接触 HFCS（0 或 50%），并在由 0、0.16 和 2.5 mg/kg OXY（3 对药物和盐水，每对 30 min)，以及对 0、0.16 和 2.5 mg/kg OXY 和体内的运动反应微透析用于测量伏隔核 (NAc) 中的多巴胺 (DA) 水平，以响应 0 和 2.5 mg/kg OXY。观察到 HFCS 暴露和对 OXY 反应之间的一组复杂的相互作用：HFCS 增加了 OXY 诱导的位置偏好，它增强了 OXY 对运动的抑制作用，并减弱了 OXY 诱导的 NAc 中 DA 溢出的升高。总之，这些发现表明营养有可能影响对阿片类药物的某些反应，这可能与其滥用有关。