A series of chalcone and flavone derivatives (6a-d, 9a-f) based on 2,4-thiazolidinedione have been synthesized and evaluated for in vivo antihyperglycemic activity in sucrose loaded (SLM) and streptozotocin (STZ) induced diabetic animal models and also for antidyslipidemic activity in the triton model. Compounds 9d, 9e, and 9f exhibited potent blood glucose-lowering activity in both SLM and STZ models. Compounds 6c, 6d, and 9c, 9e, and 9f showed moderate lipid-lowering activity. The selected most potent compounds 6d and 9e were also studied in db/db mice for both antihyperglycemic and antidyslipidemic activity.

中文翻译：

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查尔酮和黄酮类噻唑烷二酮衍生物的降血糖和降血脂药的合成及生物学评价

合成了一系列基于2,4-噻唑烷二酮的查尔酮和黄酮衍生物（6a-d，9a-f）并评估了蔗糖负载（SLM）和链脲佐菌素（STZ）诱导的糖尿病动物模型的体内抗高血糖活性Triton模型中的抗血脂异常活性。化合物9d，9e和9f在SLM和STZ模型中均显示出有效的降血糖活性。化合物6c，6d和9c，9e和9f显示出中等的降脂活性。精选的最有效化合物6d和9e还在db / db小鼠中研究了降血糖和降血脂活性。