In the widely used single-molecule Deoxyribonucleic Acid (DNA) sequencing and patch-clamp technique, the fast capacitance (C-Fast) noise in application circuit affects the accuracy of the system measurement. In this paper, a high-performance C-Fast compensation method based on compensation circuit and fuzzy adaptive algorithm is proposed. The model of C-Fast noise is analyzed and a C-Fast compensation circuit is designed, whose parameters can be automatically calculated and adjusted by fuzzy adaptive algorithm. The method is validated through simulations and experiments on the test setup. The results indicate that the proposed method can effectively eliminate the C-Fast noise and improve the measurement accuracy.

中文翻译：

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一种高性能快速电容补偿方法

在广泛使用的单分子脱氧核糖核酸（DNA）测序和膜片钳技术中，应用电路中的快速电容（C-Fast）噪声会影响系统测量的准确性。本文提出了一种基于补偿电路和模糊自适应算法的高性能C-Fast补偿方法。分析了C-Fast噪声模型，设计了C-Fast补偿电路，其参数可以通过模糊自适应算法自动计算和调整。该方法通过对测试装置的模拟和实验进行了验证。结果表明，该方法能有效消除C-Fast噪声，提高测量精度。