当前位置: X-MOL 学术Egypt. Pediatr. Assoc. Gaz. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
COVID-19 during pregnancy should we really worry from vertical transmission or rather from fetal hypoxia and placental insufficiency? A systematic review
Egyptian Pediatric Association Gazette Pub Date : 2021-04-12 , DOI: 10.1186/s43054-021-00056-0
Antoine AbdelMassih , Raghda Fouda , Rana Essam , Alhussein Negm , Dalia Khalil , Dalia Habib , George Afdal , Habiba-Allah Ismail , Hadeer Aly , Ibrahim Genedy , Layla El Qadi , Leena Makki , Maha Shulqamy , Maram Hanafy , Marian AbdelMassih , Marina Ibrahim , Mohamed Ebaid , Monica Ibrahim , Nadine El-Husseiny , Nirvana Ashraf , Noura Shebl , Rahma Menshawey , Rama Darwish , Rana ElShahawi , Rana Ramadan , Sadra Albala , Salwa Imran , Sama Ahmed , Samer Khaldi , Sara Abohashish , Stavro Paulo , Yasmin Omar , Mourad Alfy Tadros

COVID-19 is the largest outbreak to strike humanity. The wide scale of fatalities and morbidities lead to a concurrent pandemic of uncertainty in scientific evidence. Conflicting evidences are released on daily basis about the neonatal outcomes of COVID-19-positive mothers. The aim of this study was to use the relevant case reports and series to determine the percentage of newborns who test positive for COVID-19 who are born to COVID-19-positive mothers. Secondary outcomes included examining laboratory abnormalities among COVID-19-positive neonates, and any depicted placental abnormalities in COVID-19-positive mothers. For this purpose, systematic review was performed on all studies reporting primary data on fetus-mother pairs with COVID-19. Data bases were searched for studies that met our inclusion and exclusion criteria. Final screening revealed 67 studies, from which the primary data of 1787 COVID-19 mothers were identified and had their pregnancy outcome analyzed. Only 2.8% of infants born to COVID-19-positive mothers tested positive, and this finding is identical to percentages reported in former Coronaviridae outbreaks, whereas 20% manifested with intrauterine hypoxia alongside placental abnormalities suggestive of heavy placental vaso-occlusive involvement. These findings suggest that while vertical transmission is unlikely, there appears to be an underlying risk of placental insufficiency due to the prothrombotic tendency observed in COVID-19 infection. Guidelines for proper prophylactic anticoagulation in COVID-positive mothers need to be established.

中文翻译:

怀孕期间的COVID-19,我们是否应该真正担心垂直传播,或者更担心胎儿的缺氧和胎盘功能不全?系统评价

COVID-19是袭击人类的最大疫情。大量的死亡和发病率导致并发的科学证据不确定性大流行。每天都会发布有关COVID-19阳性母亲的新生儿结局的有争议的证据。这项研究的目的是使用相关的病例报告和系列文章来确定COVID-19阳性母亲所生的COVID-19呈阳性的新生儿百分比。次要结果包括检查COVID-19阳性新生儿的实验室异常,以及在COVID-19阳性母亲中发现的任何胎盘异常。为此,对所有报告COVID-19胎儿-母亲对的主要数据的研究进行了系统的综述。在数据库中搜索符合我们纳入和排除标准的研究。最终筛选显示67项研究,从中鉴定了1787名COVID-19母亲的主要数据并分析了其妊娠结局。只有2.8%的COVID-19阳性母亲出生的婴儿测试为阳性,这一发现与以前的冠状病毒科暴发中报告的百分比相同,而20%的患儿表现为宫内缺氧以及胎盘异常提示严重的胎盘血管闭塞受累。这些发现表明,尽管不太可能进行垂直传播,但由于在COVID-19感染中观察到了血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。从中确定了1787例COVID-19母亲的主要数据并对其妊娠结局进行了分析。只有2.8%的COVID-19阳性母亲出生的婴儿测试为阳性,这一发现与以前的冠状病毒科暴发中报告的百分比相同,而20%的患儿表现为宫内缺氧以及胎盘异常提示严重的胎盘血管闭塞受累。这些发现表明,尽管不太可能进行垂直传播,但由于在COVID-19感染中观察到了血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。从中确定了1787例COVID-19母亲的主要数据并对其妊娠结局进行了分析。只有2.8%的COVID-19阳性母亲出生的婴儿测试为阳性,这一发现与以前的冠状病毒科暴发中报告的百分比相同,而20%的患儿表现为宫内缺氧以及胎盘异常提示严重的胎盘血管闭塞受累。这些发现表明,尽管不太可能进行垂直传播,但由于在COVID-19感染中观察到了血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。该发现与以前的冠状病毒科暴发中报告的百分比相同,而20%的患者表现为宫内缺氧并伴有胎盘异常,提示严重的胎盘血管闭塞受累。这些发现表明,尽管不太可能进行垂直传播,但由于在COVID-19感染中观察到了血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。该发现与以前的冠状病毒科暴发中报告的百分比相同,而20%的患者表现为宫内缺氧并伴有胎盘异常,提示严重的胎盘血管闭塞受累。这些发现表明,尽管不太可能进行垂直传播,但由于在COVID-19感染中观察到了血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。由于在COVID-19感染中观察到血栓形成倾向,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。由于在COVID-19感染中观察到血栓形成趋势,因此似乎存在潜在的胎盘功能不全风险。需要建立COVID阳性母亲正确预防性抗凝的指南。
更新日期:2021-04-15
down
wechat
bug