Introduction: Molecular imaging has been developed and validated in Thai patients, comprising a portion of patients in the dementia registry. This should provide a more accurate diagnosis of the etiology of dementia, which was the focus of this study. Methods: This was a multicenter dementia study. The baseline characteristics, main presenting symptoms, and results of investigations and cognitive tests of the patients were electronically collected in the registry. Functional imaging and/or molecular imaging were performed in patients with an equivocal diagnosis of the causes of dementia, especially in atypical dementia or young onset dementia (YOD). Results: There were 454 patients in the study. The mean age of the patients was 78 years, with 60% female. Functional imaging and/or molecular imaging were performed in 57 patients (57/454 patients, 13%). The most common cause of dementia was Alzheimer’s disease (AD; 50%), followed by vascular dementia (VAD; 24%), dementia with Lewy bodies (6%), Parkinson’s disease dementia (6%), frontotemporal dementia (FTD; 2.6%), progressive supranuclear palsy (2%), multiple system atrophy (0.8%), and corticobasal syndrome (0.4%). YOD accounted for 17% (77/454 patients), with a mean age of 58 years. The causes of YOD were early onset amnestic AD (44%), VAD (16%), behavioral variant FTD (8%), posterior cortical atrophy (6.5%), and logopenic variant primary progressive aphasia (5.2%). Conclusion: AD was the most common cause of dementia in Thai patients and the distribution of other types of dementia and main presenting symptoms were similar to previous reports in Western patients; however, the proportion of YOD was higher.
Dement Geriatr Cogn Disord Extra 2021;11:64–70

中文翻译：

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泰国患者痴呆的病因学

简介：分子成像技术已在泰国患者中开发并验证，其中包括痴呆症注册表中的部分患者。这应该提供对痴呆病因的更准确诊断，这是本研究的重点。方法：这是一项多中心痴呆研究。在登记册中以电子方式收集了患者的基线特征，主要表现症状以及调查和认知测试的结果。功能性成像和/或分子成像是在对痴呆症的原因进行模棱两可的诊断的患者中进行的，尤其是在非典型性痴呆或年轻发作性痴呆（YOD）中。结果：该研究中有454位患者。患者的平均年龄为78岁，女性为60％。功能性成像和/或分子成像在57例患者中进行（57/454例患者，占13％）。痴呆最常见的原因是阿尔茨海默氏病（AD; 50％），其次是血管性痴呆（VAD; 24％），路易体痴呆（6％），帕金森氏病痴呆（6％），额颞痴呆（FTD; 2.6） ％），进行性核上性麻痹（2％），多系统萎缩（0.8％）和肾上腺皮质综合征（0.4％）。YOD占17％（77/454位患者），平均年龄为58岁。发生YOD的原因是早期发作性遗忘性AD（44％），VAD（16％），行为变异性FTD（8％），后皮质萎缩（6.5％）和低位变异性原发性进行性失语（5.2％）。结论：AD是泰国患者痴呆的最常见原因，其他类型痴呆的分布和主要表现症状与西方患者先前的报道相似。但是，YOD的比例较高。
Dement Geriatr Cogn Disord Extra 2021; 11：64–70